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マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

使用微流体工艺合成聚酯纳米颗粒以有效递送姜黄素

基本信息

批准号：
17F16720
负责人：
SHEN Amy
金额：
$ 0.7万
依托单位：
Okinawa Institute of Science and Technology Graduate University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2017
资助国家：
日本
起止时间：
2017-04-26 至 2018-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17F16720/
关键词：
Nanoprecipitation Dynamic light scattering

项目摘要

The proposed research goals are completed smoothly as expected. A novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70 nm) and narrow particle size distribution (polydispersity index less than 0.2). These results confirm that microfluidic devices for are useful in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur- PLGA NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur- PLGA NPs are stable for days, furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin. Furthermore, results from in vitro cell studies demonstrate the potential of our Cur-PLGA NP as an effective delivery system for curcumin. Our microfluidic assisted approach offers a controlled and effective nano-biomaterials synthesis of drug delivery system for curcumin, which can be extended to different capsule materials for a variety of biomedical applications. These results have been presented in international symposium and conference and has been published in an international peer-reviewed journal.

所提出的研究目标按预期顺利完成。一种新的微流体辅助纳米沉淀策略，其能够合成无表面活性剂的姜黄素封装的聚（丙交酯-共-乙交酯）纳米颗粒（Cur-PLGA NP），其具有可调节的粒径（30-70 nm）和窄的粒度分布（多分散指数小于0.2）。这些结果证实了微流体装置可用于开发用于药物递送的新型聚酯纳米颗粒。除了合成的Cur-PLGA NP的物理表征之外，还使用UV-vis光谱研究了其在溶液中的降解动力学。结果表明，这些Cur-PLGA纳米颗粒可稳定数天，此外，包封的姜黄素分子在水性环境中显著溶解和稳定。我们的Cur-PLGA NP具有优异的胶体稳定性并抑制姜黄素的降解。此外，来自体外细胞研究的结果证明了我们的Cur-PLGA NP作为姜黄素的有效递送系统的潜力。我们的微流控辅助方法为姜黄素提供了一种可控和有效的纳米生物材料合成药物递送系统，其可以扩展到各种生物医学应用的不同胶囊材料。这些结果已在国际研讨会和会议上提出，并已在国际同行评审期刊上发表。