マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

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The proposed research goals are completed smoothly as expected. A novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70 nm) and narrow particle size distribution (polydispersity index less than 0.2). These results confirm that microfluidic devices for are useful in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur- PLGA NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur- PLGA NPs are stable for days, furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin. Furthermore, results from in vitro cell studies demonstrate the potential of our Cur-PLGA NP as an effective delivery system for curcumin. Our microfluidic assisted approach offers a controlled and effective nano-biomaterials synthesis of drug delivery system for curcumin, which can be extended to different capsule materials for a variety of biomedical applications. These results have been presented in international symposium and conference and has been published in an international peer-reviewed journal.