Analysis and therapeutic application of intestinal epithelial cell plasticity in inflammatory bowel disease
Analysis and therapeutic application of intestinal epithelial cell plasticity in inflammatory bowel disease
批准号:
16H05284
负责人:
Okamoto Ryuichi
金额:
$11.07万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2016
资助国家:
日本
项目状态:
已结题
起止时间:
2016-04-01 至 2019-03-31
中文摘要
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Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells
来自牛角瓜的 Notch 抑制剂可诱导神经干细胞的神经元分化
DOI:
10.1021/acs.jnatprod.7b00282
发表时间:
2017
期刊:
Journal of Natural Products
影响因子:
5.1
作者:
[Yoneyama Tatsuro, Arai Midori A., Akamine Ryuta, Koryudzu Kazune, Tsuchiya Anna, Sadhu Samir K., Ahmed Firoj, Itoh Motoyuki, Okamoto Ryuichi, Ishibashi Masami]
通讯作者:
Ishibashi Masami
Synergy of Notch signalling and TNF-alpha in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein.
IBD 患者发炎的肠上皮细胞中 Notch 信号传导和 TNF-α 的协同作用导致 UBD(一种泛素样蛋白)上调。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Kawamoto A, Nagata S, Anzai S, Okamoto R, Mamoru Watanabe et al.]
通讯作者:
Mamoru Watanabe et al.
Jagged1 is indispensable for the maintenance of tumor stem cell niche in APC-Deficient intestinal adenomas
Jagged1对于APC缺陷型肠腺瘤中肿瘤干细胞生态位的维持是不可或缺的
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Toru Nakata, Go Ito, Hiromichi Shimizu, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Ryuichi Okamoto, Mamoru Watanabe]
通讯作者:
Mamoru Watanabe
クローン病由来の小腸上皮オルガノイド構築による幹細胞形質の解析
通过构建源自克罗恩病的小肠上皮类器官来分析干细胞特性
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[鈴木康平, 村野竜朗, 平栗優衣, 高橋純一, 河本亜美, 石橋史明 , 安斎 翔, 久野玲子, 桒原小の実, 川井麻央, 永田紗矢香, 油井史郎, 土屋輝一郎, 中村哲也, 大塚和朗, 渡辺 守, 岡本隆一]
通讯作者:
岡本隆一
Single-cell level analysis reveals heterogeneous expression of stem-cell specific genes in human small intestinal organoids
单细胞水平分析揭示人类小肠类器官中干细胞特异性基因的异质表达
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Kohei Suzuki, Satoru Fujii, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Otsuka, Ryuichi Okamoto, Mamoru Watanabe]
通讯作者:
Mamoru Watanabe
共 7 条
Development of primitive-gut-derived organ bioengineering methods based on spheroid designing.
-
批准号:20K21597
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.16万
-
财政年份:2020
-
负责人:Okamoto Ryuichi
-
依托单位:
Identification and functional analysis of colonic label-retaining goblet cells for the application to regeneration of the inflamed mucosa.
-
批准号:19H03634
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2019
-
负责人:Okamoto Ryuichi
-
依托单位:
Theoretical study of steric effects in electrolyte solutions: Toward thorough understanding of Hofmester effect
-
批准号:18K03562
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2018
-
负责人:Okamoto Ryuichi
-
依托单位:
Establishment of enterohormone farm by using cultured human intestinal epithelial cells
-
批准号:15K15286
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:Okamoto Ryuichi
-
依托单位:
Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formation
-
批准号:25293170
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.81万
-
财政年份:2013
-
负责人:Okamoto Ryuichi
-
依托单位:
海外基金