Dysregulation of AKT network and its application for precision medicine in lung cancer

AKT网络失调及其在肺癌精准医疗中的应用

• 批准号: 17K08727
• 负责人: Dobashi Yoh
• 金额: $ 3万
• 依托单位: International University of Health and Welfare (2020-2021)Jichi Medical University (2017-2019)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08727/
• 关键词: Trefoil factor-1; mTOR; 肺癌; 増殖抑制; 遊走; 浸潤; バイオマーカー; TFF1-3; アポトーシス; 蛍光免疫染色; 浸潤能; TFF-1; 浸潤抑制; abortive cell cycle; 転写制御; 乳癌; Akt; 遺伝子増幅; MLPA; FISH; p27; ubiquitin ligase; ELISA; microRNA; trefoil factor; 遺伝子多型

项目成果

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

• DOI: 10.1016/j.ygeno.2019.07.008
• 发表时间: 2019-07
• 期刊: Genomics
• 影响因子: 4.4
• 作者: J. Wong;Han Zhang;C. Hsiung;K. Shiraishi;Kai Yu;K. Matsuo;M. Wong;Yun-Chul Hong;Jiucun Wang;W. Seow;Zhaoming Wang;Minsun Song;H. Kim;I. Chang;N. Chatterjee;Wei Hu;Chen Wu;T. Mitsudomi;W. Zheng;J. H. Kim;A. Seow;N. Caporaso;M. Shin;L. Chung;S. An;Ping Wang;Yang Yang-Yang;Hong Zheng;Y. Yatabe;Xuchao Zhang;Y. T. Kim;Q. Cai;Zhihua Yin;Young-chul Kim;B. Bassig;Jiang Chang;J. Ho;B. Ji;Y. Daigo;Hidemi Ito;Y. Momozawa;K. Ashikawa;Y. Kamatani;T. Honda;H. Hosgood;H. Sakamoto;H. Kunitoh;K. Tsuta;Shun-ichi Watanabe;M. Kubo;Y. Miyagi;H. Nakayama;S. Matsumoto;M. Tsuboi;K. Goto;Jianxin Shi;L. Song;X. Hua;A. Takahashi;A. Goto;Y. Minamiya;K. Shimizu;Kazumi Tanaka;F. Wei;F. Matsuda;J. Su;Yeul-Hong Kim;I. Oh;F. Song;W. Su;Yu-Min Chen;G. Chang;Kuan-Yu Chen;Ming-Shyan Huang;L. Chien;Y. Xiang;J. Park;S. Kweon;Chien-Jen Chen;Kyoung-Mu Lee;Batel Blechter;Haixin Li;Yu-Tang Gao;B. Qian;D. Lu;Jianjun Liu;H. Jeon;C. Hsiao;J. Sung;Y. Tsai;Y. Jung;Huan Guo;Zhibin Hu;Wen-Chang Wang;Charles C. Chung;L. Burdett;M. Yeager;A. Hutchinson;S. Berndt;Wei Wu;H. Pang;Yuqing Li;J. Choi;K. Park;S. Sung;Li Liu;C. Kang;M. Zhu;Chung-Hsing Chen;Tsung-Ying Yang;Jun Xu;P. Guan;W. Tan;Chih-Liang Wang;M. Hsin;Ko-Yung Sit;J. Ho;Ying Chen;Y. Choi;J. Hung;Jun Suk Kim;H. Yoon;Chien-Chung Lin;I. Park;P. Xu;Yuzhuo Wang;Qincheng He;R. Perng;Chih-Yi Chen;R. Vermeulen;Junjie Wu;W. Lim;Kun-Chieh Chen;Yao-Jen Li;Jihua Li;Hongyan Chen;Chong-Jen Yu;Li Jin;Tzu-Yu Chen;S. Jiang;Jie Liu;T. Yamaji;B. Hicks;Kathleen Wyatt;Shengchao A Li;J. Dai;Hongxia Ma;G. Jin;B. Song;Zhehai Wang;Sensen Cheng;Xuelian Li;Yangwu Ren;P. Cui;M. Iwasaki;T. Shimazu;S. Tsugane;Junjie Zhu;Ying Chen;Kaiyun Yang;G. Jiang;K. Fei;Guoping Wu;Hsien-Chin Lin;Hui-Ling Chen;Yao-Huei Fang;Fang‐Yu Tsai;W. Hsieh;Jinming Yu;V. Stevens;I. Laird-Offringa;C. Marconett;Linda Rieswijk;A. Chao;Pan‐Chyr Yang;X. Shu;Tangchun Wu;Y. Wu;D. Lin;Kexin Chen;Baosen Zhou;Yunchao Huang;T. Kohno;Hongbing Shen;S. Chanock;N. Rothman;Q. Lan

Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes

• DOI: 10.15252/embr.202052190
• 发表时间: 2021-07
• 期刊: EMBO reports
• 影响因子: 7.7
• 作者: Yuka Tamura;T. Ohhata;Hiroyuki Niida;Satoshi Sakai;C. Uchida;K. Masumoto;F. Katou;A. Wutz;M. Kitagawa

EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.

EphA2 是 miR-200a 的可能靶标，在人肺癌中通过 AKT2 通路发挥作用。

• 发表时间: 2020
• 期刊: Int J Clin Exp Pathol.
• 作者: Tsubochi H;Minegishi K;Goto A;Nakamura R;Matsubara D;Dobashi Y.
• 通讯作者: Dobashi Y.

mTORにより制御されるtrefoil faactor-1と肺癌におけるその意義

mTOR调控的三叶因子1及其在肺癌中的意义

• 发表时间: 2019
• 作者: 土橋 洋;山田 茂樹;中村 律子;椙村 春彦;大井 章史
• 通讯作者: 大井 章史

TGF βによって誘導され、TGF β-Smadシグナリングの正の制御因子として機能する新規lncRNA ELIT-1

由 TGF β 诱导的新型 lncRNA ELIT-1 并作为 TGF β-Smad 信号传导的正调节因子

• 发表时间: 2019
• 作者: 北川雅敏;酒井聡;大畑樹也
• 通讯作者: 大畑樹也