Novel strategy for the development of therapeutics against autoimmune disease of the central nervous system, utilizing the crosstalk of cells forming blood-brain barrier.
Novel strategy for the development of therapeutics against autoimmune disease of the central nervous system, utilizing the crosstalk of cells forming blood-brain barrier.
批准号:
17H04197
负责人:
KANDA Takashi
金额:
$10.82万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2017
资助国家:
日本
项目状态:
已结题
起止时间:
2017-04-01 至 2020-03-31
中文摘要
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英文摘要
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BBB構成細胞による継時的バリア評価モデルの開発とIL-6受容体阻害が視神経脊髄炎のBBB破綻に与える効果検証
使用 BBB 组成细胞开发连续屏障评估模型并验证 IL-6 受体抑制对视神经脊髓炎 BBB 破坏的影响
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[竹下幸男, 芹澤賢一, 藤川 晋, 清水文崇, 藤澤美和子, 古賀道明, 神田 隆]
通讯作者:
神田 隆
神経系のバリアー機能とその分子構造
神经系统的屏障功能及其分子结构
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee, et al T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L,, 神田 隆]
通讯作者:
神田 隆
The effect of blood-brain barrier (BBB)-specific laminins for barrier function with a new in vitro BBB model incorporating multi-culturing system of BBB components.
血脑屏障 (BBB) 特异性层粘连蛋白对屏障功能的影响,采用结合 BBB 成分多元培养系统的新型体外 BBB 模型。
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Takeshita Y, Fujikawa S, Shimizu F, Sano Y, Maeda T, Kanda T]
通讯作者:
Kanda T
DOI:
10.1126/scitranslmed.aai9111
发表时间:
2017-07-05
期刊:
Science translational medicine
影响因子:
17.1
作者:
[Shimizu F, Schaller KL, Owens GP, Cotleur AC, Kellner D, Takeshita Y, Obermeier B, Kryzer TJ, Sano Y, Kanda T, Lennon VA, Ransohoff RM, Bennett JL]
通讯作者:
Bennett JL
シンポジウム:「神経免疫疾患の病態解明への多面的アプローチ」血液脳関門からのアプローチ
研讨会:“阐明神经免疫疾病病理学的多方面方法”从血脑屏障出发
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Yokota K, Nozu K, Minamikawa S, Yamamura T, Nakanishi K, Kaneda H, Hamada R, Nozu Y, Shono A, Ninchoji T, Morisada N, Ishimori S, Fujimura J, Horinouchi T, Kaito H, Nakanishi K, Morioka I, Taniguchi-Ikeda M, Iijima K., 神田 隆]
通讯作者:
神田 隆
共 18 条
Novel strategy to alter the internal milieu of peripheral nervous system targeting BNB-forming pericytes
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批准号:26670443
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2014
-
负责人:KANDA Takashi
-
依托单位:
Analysis and manipulation of acellular barrier in human blood-nerve barrier
-
批准号:25293203
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2013
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负责人:KANDA Takashi
-
依托单位:
Comprehensive establishment of human immortalized cell lines originating from central and peripheral nervous system
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批准号:23659457
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2011
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负责人:KANDA Takashi
-
依托单位:
Artificial control of blood-nerve barrier : an approach toward the novel therapeutics of intractable human peripheral nervous system disorders
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批准号:21390268
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2009
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负责人:KANDA Takashi
-
依托单位:
Blood-brain barrier and blood-nerve barrier as targets of novel therapeutic strategies for neurological disorders
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批准号:18390259
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.53万
-
财政年份:2006
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负责人:KANDA Takashi
-
依托单位:
Effect of FGF-9 on cultured neurons : novel approach for the treatment of neurodegenerative disorders
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批准号:10557060
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$5.82万
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财政年份:1998
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负责人:KANDA Takashi
-
依托单位:
Cell biology of blood-nerve barrier, using cultured endothelial cell of endoneurial microvessel origin
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批准号:10670578
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1998
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负责人:KANDA Takashi
-
依托单位:
Cellular and Molecular Study of Blood-Nerve Barrier
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批准号:07670703
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:KANDA Takashi
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依托单位:
海外基金