Comprehensive establishment of human immortalized cell lines originating from central and peripheral nervous system

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Human immortalized cell lines originating from central and peripheral nervous system are potent tool to understand the molecular and physiological properties of cells composing the human nervous system. The aim of this study is to comprehensively establish the human cell lines of central and peripheral nervous system origin which retain original cellular properties. In this study period, we finally established (1) microvascular endothelial cell line and pericyte cell line of human skeletal muscle, and (2) microvascular endothelial cell line and pericyte cell line of human spinal cord. These immortalized cell lines adequately keep cellular properties of cells in vivo, and thus will be widely used as potent research tools for the human muscle disorders and spinal cord diseases including multiple sclerosis and neuromyelitis optica.