Elucidation of phylogenetic processes during early evolution of basal Metazoa through the phylogenetic study of both, selected molecular marker genes and EST data

通过对选定的分子标记基因和 EST 数据的系统发育研究，阐明基础后生动物早期进化过程中的系统发育过程

• 批准号: 5453326
• 负责人: Dr. Matthias P. Wiens
• 金额: --
• 依托单位: Institut für Physiologische Chemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5453326?language=en
• 关键词: Elucidation; phylogenetic; processes; during; early

Phylogenetic relationships of early branching Metazoa and the origin of animal life have been subject to unrelenting controversies since inferences from morphological and molecular analyses are often conflicting. Uncertainty not only surrounds the interrelationships between metazoan phyla (i. e., the relative branchings of Porifera, Cnidaria, Ctenophora, and Bilateria) but also concerns many other systematic levels (e. g., monophyly/paraphyly of Porifera and poriferan classes, evolutionary origin of freshwater sponges, etc.). In addition, the placement of choanoflagellates on the eukaryotic tree remains obscure, even though several studies suggest a close relationship to Metazoa or even consider choanoflagellates as a member of Metazoa. The aim of this renewal proposal is to further address these conflicting hypotheses and also to establish a phylogenetic framework that allows studying metazoan evolution. So far, phylogenetic rDNA analyses have not been able to resolve these conflicts unambiguously. Therefore, we will continue to generate EST data and to sample protein-coding loci of basal Metazoa (including choanoflagellates, sponges, and cnidarians), concentrating on an extensive selection of genes that code for enzymes of metabolic pathways, metazoan specific proteins, and proteins involved in poriferan morphogenesis/spiculogenesis. Since shape and composition of spicules are the basis for sponge classification, it is tempting to consider their genetic background under a phylogenetic point of view. With this combined data we will attempt to extrapolate from gene trees to organismal trees.

早期分支后生动物的系统发育关系和动物生命的起源一直受到无情的争议，因为从形态和分子分析的推论往往是相互矛盾的。不确定性不仅围绕着后生动物门之间的相互关系（即。例如，Porifera，Cnidaria，Ctenophora和Bilateria的相对分支），但也涉及许多其他系统水平（e.例如，在一个实施例中，多孔动物门和多孔动物门的单系/并系，淡水海绵的进化起源等）。此外，领鞭毛虫在真核生物树上的位置仍然模糊，尽管一些研究表明与后生动物有密切的关系，甚至认为领鞭毛虫是后生动物的一员。这个更新建议的目的是进一步解决这些相互矛盾的假设，并建立一个系统发育框架，允许研究后生动物的进化。到目前为止，系统发育rDNA分析还不能明确地解决这些冲突。因此，我们将继续产生EST数据和样品的蛋白质编码基因座的基础后生动物（包括choanoflagellates，海绵，刺胞动物），集中在广泛的选择基因编码酶的代谢途径，后生动物特异性蛋白质，蛋白质参与poriferan形态/spiculogenesis。由于骨针的形状和组成是海绵分类的基础，因此从系统发育的角度考虑它们的遗传背景是很诱人的。有了这些综合数据，我们将尝试从基因树推断到生物树。

项目成果

The 2'-5'-oligoadenylate synthetase in the lowest metazoa: isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensis.

• DOI: 10.1016/j.molimm.2007.07.036
• 发表时间: 2008-02
• 期刊: Molecular immunology
• 影响因子: 3.6
• 作者: H. Schröder;F. Natalio;M. Wiens;M. Tahir;M. Shukoor;W. Tremel;S. Belikov;A. Krasko;W. Müller

Assessing the root of bilaterian animals with scalable phylogenomic methods

• DOI: 10.1098/rspb.2009.0896
• 发表时间: 2009-12-22
• 期刊: PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
• 影响因子: 4.7
• 作者: Hejnol, Andreas;Obst, Matthias;Dunn, Casey W.
• 通讯作者: Dunn, Casey W.

Toll-like receptors are part of the innate immune defense system of sponges (demospongiae: Porifera).

• DOI: 10.1093/molbev/msl208
• 发表时间: 2006-12
• 期刊: Molecular biology and evolution
• 影响因子: 10.7
• 作者: M. Wiens;M. Korzhev;S. Perović-Ottstadt;B. Luthringer;David Brandt;S. Klein;W. Müller

Poriferan survivin exhibits a conserved regulatory role in the interconnected pathways of cell cycle and apoptosis

• DOI: 10.1038/cdd.2010.87
• 发表时间: 2011-02-01
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Luthringer, B.;Isbert, S.;Wiens, M.
• 通讯作者: Wiens, M.

Regional and modular expression of morphogenetic factors in the demosponge Lubomirskia baicalensis.

黄芩海绵中形态发生因子的区域和模块化表达

• DOI: 10.1016/j.micron.2007.02.003
• 发表时间: 2008
• 期刊: Micron
• 影响因子: 2.4
• 作者: Wiens M;Belikov S.I;Kaluzhnaya O.V;Adell T;Schröder H.C;Perovic-Ottstadt S;Kaandorp J.A;Müller W.E.G.
• 通讯作者: Müller W.E.G.