Elucidation of the mechanism of mesenchymal stem cell abnormality causing ossification of spinal ligament and target search of therapeutic agents based on the mechanism

阐明间充质干细胞异常导致脊柱韧带骨化的机制并基于该机制寻找治疗药物的靶点

• 批准号: 17K10916
• 负责人: Furukawa Kenichi
• 金额: $ 2.91万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10916/
• 关键词: 間葉系幹細胞; 異所性骨化; 脊柱靭帯; エピジェネティクス; メカニカルストレス; DNAメチル化; 生理活性物質; スクリーニング; 脊柱靭帯骨化症; 形質転換; 天然生理活性物質; 骨化抑制; 細胞遊走; SDF-1; CXCR4; コンドロモジュリン; 内軟骨性骨化; 治療薬

项目成果

Blood coagulability, vascular morphology and vasculogenesis capability of spinal ligament ossification model mice

脊髓韧带骨化模型小鼠的凝血功能、血管形态及血管生成能力

• 发表时间: 2020
• 作者: 岩瀬正顕;淺井昭雄;須山武裕;島田志行;山村奈津美;市川尚己;Nana Ichikawa
• 通讯作者: Nana Ichikawa

Role of SDF-1/CXCR4 Axis in Chemotactic Behavior of Mesenchymal Stem Cell in Ossified Human Spinal Ligaments.

SDF-1/CXCR4 轴在骨化人脊柱韧带间充质干细胞趋化行为中的作用。

• 发表时间: 2019
• 作者: Chin Shunfu;Furukawa Ken-Ichi;Wada Kanichiro;Kumagai Gentaro;Kudo Hitoshi;Asari Tohru;Ichikawa Nana;Araki Ryo;Ishibashi Yasuyuki
• 通讯作者: Ishibashi Yasuyuki

Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor

华法林通过孕烷 X 受体在高磷酸盐条件下钙化人主动脉瓣间质细胞

• DOI: 10.1007/s00774-019-01001-3
• 发表时间: 2019
• 期刊: Journal of Bone and Mineral Metabolism
• 影响因子: 3.3
• 作者: Yu Zaiqiang;Seya Kazuhiko;Chiyoya Mari;Daitoku Kazuyuki;Motomura Shigeru;Imaizumi Tadaatsu;Fukuda Ikuo;Furukawa Ken-Ichi
• 通讯作者: Furukawa Ken-Ichi

Suppression of osteogenic differentiation in mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament by a histamine-2-receptor antagonist

• DOI: 10.1016/j.ejphar.2017.07.013
• 发表时间: 2017-09-05
• 期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
• 影响因子: 5
• 作者: Liu, Xizhe;Kumagai, Gentaro;Ishibashi, Yasuyuki
• 通讯作者: Ishibashi, Yasuyuki

High Osteogenic Potential of Adipose- and Muscle-derived Mesenchymal Stem Cells in Spinal-Ossification Model Mice.

• DOI: 10.1097/brs.0000000000002266
• 发表时间: 2017-12-01
• 期刊: Spine
• 影响因子: 3
• 作者: Liu X;Kumagai G;Wada K;Tanaka T;Asari T;Oishi K;Fujita T;Mizukami H;Furukawa KI;Ishibashi Y
• 通讯作者: Ishibashi Y