SFB 355: Pathophysiology of Heart Failure

SFB 355：心力衰竭的病理生理学

• 批准号: 5478531
• 金额: --
• 依托单位: Julius-Maximilians-Universität Würzburg
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 1993
• 资助国家: 德国
• 起止时间: 1992-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5478531?language=en
• 关键词: SFB; 355; Pathophysiology; Heart; Failure

The central theme of the collaborative research centre is the study of the causes, consequences, and therapy of heart failure. The heart failure syndrome results primarily from heart and circulatory diseases such as coronary heart disease, myocardial infarction, hypertension, and has a major medical and socio-economic impact due to its increasing incidence. The multifactorial etiology and complex consequences for other organ systems requires an interdisciplinary research approach. Research groups of section A (Nuclear Magnetic Resonance) develop new NMR methods for analysis of cardiac morphology, circulation, metabolism, and function. These methods are applied a) to pathophysiological mechanisms of heart failure, and b) to clinical studies of patients treated for heart failure. Section B (Pathophysiology) investigates the basic mechanisms of development of chronic heart failure after myocardial infarction, especially the role of endogenous hormones (renin, angiotensin, endothelin, atrial natriuretic factors, and nitric oxide), endothelial cells, and important regulators of calcium homeostasis. Section C (Pathobiochemistry and Molecular Biology) focuses on analyses of cell and molecular biology of the functions of receptors for hormones as well as adhesion and growth factors, and their significance with respect to heart failure. Furthermore, genetically engineered transgenic mice are being developed and examined as animal models of heart disease in the Würzburg collaborative research centre 355 using the recently developed methods in biochemistry, pharmacology, physiology, and physics. In 2002, the DFG granted an additional young investigator group focussing on the effectors of endothelial permeability.

合作研究中心的中心主题是研究心力衰竭的原因，后果和治疗。心力衰竭综合征主要由心脏和循环系统疾病如冠心病、心肌梗死、高血压引起，并且由于其发病率的增加而具有重大的医学和社会经济影响。多因素病因学和其他器官系统的复杂后果需要跨学科的研究方法。A部分（核磁共振）的研究小组开发了新的核磁共振方法，用于分析心脏形态，循环，代谢和功能。这些方法应用于a）心力衰竭的病理生理学机制，和B）心力衰竭治疗患者的临床研究。B部分（病理生理学）研究了心肌梗死后慢性心力衰竭发展的基本机制，特别是内源性激素（肾素、血管紧张素、内皮素、心钠素和一氧化氮）、内皮细胞和钙稳态的重要调节剂的作用。C部分（病理生物化学和分子生物学）侧重于激素受体以及粘附和生长因子功能的细胞和分子生物学分析，以及它们在心力衰竭中的意义。此外，维尔茨堡合作研究中心355正在利用最近开发的生物化学、药理学、生理学和物理学方法，开发和研究基因工程转基因小鼠作为心脏病动物模型。2002年，DFG批准了一个额外的年轻研究小组，专注于内皮通透性的效应。