SFB 638: Dynamics of Macromolecular Complexes in Biosynthetic Transport

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The Collaborative Research Centre aims at analysing the dynamics of complex multiprotein systems that cause folding, intracellular transport and specific localisation of macromolecules. Dynamics are of interest i) at a cell biological level to describe the formation of higher complexes by protein/protein, protein/nucleic acid, and protein lipid interactions central for all projects of the program, and ii) with respect to the kinetics of changes within such individual complexes, e.g. their conformational change, polymerisation or formation of subcomplexes. This aspect will be analysed by biochemical/biophysical methods in some of the projects. A complementation and extension of topics is reached specifically by combining virological and molecular cell biological projects within a mutual initiative. Synergetic effects will arise from similar concepts and questions asked in these fields of biological research.