How does zinc-rich food promotes sleep: a role for Gut-Brain Axis?

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A lack of sleep is associated with long-term health consequences (diabetes, high blood pressure, heart disease) and these conditions may lead to a shortened life expectancy. We recently identified Zinc as a powerful modulator of sleep. Zinc-containing food dose dependently increased the total amount of non-rapid eye movement (NREM) sleep in mice and in humans. This is the first evidence ever published that zinc can actually modulate sleep (Cherasse et al., Mol. Nutr. Food Res., 2015). In addition, we also found that Japanese people with low serum zinc concentration sleeps poorly. In a randomized controlled trial, we produced evidence that chronically absorbing a proper amount of zinc has beneficial effects on Japanese citizen’s sleep (Saito, Cherasse et al., Mol. Nutr. Food. Res., 2017).