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KFO 208: Aetiology and Sequelae of Periodontal Diseases - Genetic, Cell Biological and Biomechanical Aspects

KFO 208：牙周病的病因学和后遗症 - 遗传、细胞生物学和生物力学方面

基本信息

批准号：
58918792
负责人：
金额：
--
依托单位：
Zentrum für Zahn-, Mund- und Kieferheilkunde
依托单位国家：
德国
项目类别：
Clinical Research Units
财政年份：
2008
资助国家：
德国
起止时间：
2007-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/58918792?language=en
关键词：
KFO 208 Aetiology Sequelae Periodontal

项目摘要

Periodontitis is a complex multifactorial disease and the exact aetiopathogenetic mechanisms are still largely unknown. The projects of the Clinical Research Unit are thus devoted to the inflammatory, tissue-destructive and regenerative processes in the periodontium as well as the possible sequelae for general health in the context of in-vitro, animal and clinical studies. The major goal of the Clinical Research Unit is to improve the prevention, disease control and therapy of periodontitis through a better understanding of the causes and effects of periodontal diseases as well as of regenerative processes in the involved tissues. The Clinical Research Unit embarks on an interdisciplinary research approach that comprises genetic, cell biological and biomechanical aspects. The identification of periodontitis-associated genetic polymorphisms as well as biomechanical and vascular factors that influence the periodontal situation should enable patients at risk to be recognised and therapy to be carried out at an earlier stage than has been possible until now. New therapeutic approaches are expected as a result of identifying and characterising dendritic cell populations and the effects mediated by beta-defensin. By clarifying the significance of periodontal diseases for vascular pathology and especially the significance of vascular regeneration for the treatment of periodontitis, new forms of therapy may possibly result that, through a systemic approach, could both reduce the health risks for the entire patient and also improve the success of local treatment. Furthermore, a major focus is given to biomechanical aspects in the context of periodontal wound healing and possible consequences for regenerative treatment strategies. The investigation of the mechanisms whereby enamel matrix derivatives, insulin-like growth factors and parathyroid hormone mediate their effects at cellular and molecular levels will reveal their potential for application in regenerative periodontal therapy.

牙周炎是一种复杂的多因素疾病，确切的病因发病机制仍在很大程度上是未知的。因此，临床研究部门的项目致力于牙周组织的炎症、组织破坏和再生过程，以及在体外、动物和临床研究的背景下对一般健康可能产生的后遗症。临床研究单位的主要目标是通过更好地了解牙周病的原因和影响以及相关组织的再生过程来改善牙周炎的预防，疾病控制和治疗。临床研究部门开始了跨学科的研究方法，包括遗传学，细胞生物学和生物力学方面。识别牙周炎相关的遗传多态性以及影响牙周状况的生物力学和血管因素，应使患者在风险被识别和治疗进行在较早的阶段比已经可能到现在。新的治疗方法，预计由于识别和表征树突状细胞群体和β-防御素介导的影响。通过阐明牙周病对血管病理学的重要性，特别是血管再生对牙周炎治疗的重要性，可能会产生新的治疗形式，通过系统方法，既可以降低整个患者的健康风险，也可以提高局部治疗的成功率。此外，主要关注的是牙周伤口愈合背景下的生物力学方面以及再生治疗策略可能产生的后果。釉基质衍生物，胰岛素样生长因子和甲状旁腺激素介导的作用在细胞和分子水平的机制的调查将揭示其在再生牙周治疗中的应用潜力。