The NMDA-receptor activated nuclear import of Jacob: A signaling pathway regulating learning-induced gene expression? (B08)

NMDA 受体激活 Jacob 的核输入：调节学习诱导基因表达的信号通路？

• 批准号: 63915869
• 金额: --
• 依托单位: Forschungsgruppe Neuroplastizität
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/63915869?language=en
• 关键词: NMDA; receptor; activated; nuclear; import

Information storage in neuronal networks essentially requires activity-dependent gene expression that impacts on the structure and flexibility of synaptic contacts. In this project we are dealing with the question how dopamine and BDNF modlated synaptic NMDAR signals are conveyed to the nucleus and how the genomic response to this signaling feeds back to synaptic structure and function. The Jacob pathway is a signaling pathway that couples NMDA-receptor activity to CREB-mediated gene expression. In the proposed project we will test whether nuclear import of Jacob is involved in global and input specific synaptic scaling processes that are relevant for hippocampus-dependent learning and memory.

神经元网络中的信息存储本质上需要影响突触接触的结构和灵活性的活性依赖性基因表达。在这个项目中，我们正在处理的问题，多巴胺和BDNF调制的突触NMDAR信号是如何传递到细胞核和基因组如何响应这种信号反馈到突触的结构和功能。Jacob途径是将NMDA受体活性与CREB介导的基因表达偶联的信号传导途径。在拟议的项目中，我们将测试是否雅各布核进口参与全球和输入特定的突触缩放过程，相关的海马依赖的学习和记忆。