増殖糖尿病網膜症・老人性白内障の分子病理学的研究

增殖性糖尿病视网膜病变与老年性白内障的分子病理学研究

• 批准号: 08877266
• 负责人: 大庭 紀雄
• 金额: $ 1.22万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08877266/
• 关键词: 糖尿病網膜症; 老人性白内障; ミトコンドリア遺伝子; 細膜; 水晶体

増殖糖尿病網膜症・老人性白内障の成因を求めるために、末梢血および眼局所病巣におけるミトコンドリア遺伝子(mtDNA)を検索した.2年間の研究によって以下の成果を得た.1.増殖糖尿病網膜症の手術時に得た網膜硝子体病巣のmtDNAを45例について検索した.わずかに1例であるが、mtDNA3243に塩基置換によるミスセンス変異があった.この症例は家族性糖尿病に罹患していた.ただし、末梢血には変異を見い出すことができなかった.残りの症例には、家族性罹患例を多数含んでいたが、末梢血および病巣局所にmtDNA変異はみなかった.すなわち、重症糖尿病網膜症の成因には、例外を除くと、mtDNAの変異は関与していないことを示した.2.老人性白内障の手術時に得た水晶体試料55例についてmtDNAを検索した.欠失あるいは点変異を示す事例はまったくなかった.すなわち、加齢に伴う水晶体の混濁にはmtDNAの加齢変化は関与しないことを示した.3.高齢者の網膜、特に黄斑部について剖検試料30例を対象にしてmtDNAを検索した.欠失あるいは点変異を示す事例はまったくなかった.すなわち、加齢に伴う網膜とくに黄斑部の変化にはmtDNAの加齢変化は関与しないことを示した.

The causes of human cataract in patients with diabetic retinopathy were investigated in terms of the causes of cataract, peripheral blood, peripheral blood and eye disease. 2 years of research has been carried out and the following results have been obtained. 45 patients with diabetic retinopathy were diagnosed with mtDNA during the onset of diabetic retinopathy. In one case, mtDNA3243 was found to be in a bad condition, and there was a problem. A case of familial diabetes is suffering from diabetes mellitus. There's a lot of blood on the end, and there's a lot of blood on the end. Most of the cases of disability and familial disease include mtDNA disease, peripheral blood disease and other diseases. The causes of severe diabetic retinopathy, the cause of severe diabetic network disease, the exception exception, the mtDNA diagnosis and the etiology of severe diabetic retinopathy. 2. 55 cases of senile cataract with cataract were diagnosed by mtDNA. I don't know how to show you a case. I don't know. The crystal is mixed with the crystal, the mtDNA is mixed with the crystal, and the crystal is modified. 3. A total of 30 cases of high-risk patients with network and special macular diseases were expected to have the symptoms of abnormal mtDNA. I don't know how to show you a case. I don't know. On the Internet, on the Internet, on the macula, on the mtDNA, on the Internet, on the Internet, on the macula, on the macula.

项目成果

Ohba N,Nakao K: "HTLV-I associated retinochoroidal degeneration" Jpn J Ophthalmol. 40. 71-78 (1996)

Ohba N，Nakao K：“HTLV-I 相关的视网膜脉络膜变性”Jpn J Ophamol。

Uehara F,Ohba N,et al: "Sialyglycuconjugates and hetinal degeneration" Retinal Degeneration and Regeneration. 1. 73-80 (1996)

Uehara F，Ohba N，et al：“Sialyglycuconjugates 和 hetinal 变性”视网膜变性和再生。

Isashiki Y,Ohba N,et al: "Assessment of nitochondrial gene in proliferative vitneoretinal tissues from patients with familial diabetes mellitus" Jpn J Ophthalmol. 40. 66-70 (1996)

Isashiki Y、Ohba N 等人：“家族性糖尿病患者增殖性玻璃体视网膜组织中线粒体基因的评估”Jpn J Ophthalmol。