Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing

使用智能增材生物制造工程组织组织

• 批准号: DE220100757
• 负责人: Dr Mark Allenby
• 金额: $ 32.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-07 至 2025-03-06
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100757
• 关键词: Engineering; Tissue; Organisation; Using; Intelligent

This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitative and predictive understanding of how to control biological processes within 3D printed environments will design and engineer more robust, customisable, scalable, and economical cell culture platforms able to optimally manufacture bespoke and complex 3D tissues for future agricultural, pharmaceutical, or medical products.

该项目旨在通过控制细胞行为的3D打印结构来组织和塑造实验室培养组织的形成。这种细胞行为控制将通过跨学科和多尺度的增材微制造、生物反应器工程、细胞培养、单细胞成像和计算建模来完成。与目前的经验方法相比，这种对如何在3D打印环境中控制生物过程的定量和预测性理解将设计和设计更强大、可定制、可扩展和经济的细胞培养平台，能够为未来的农业、制药或医疗产品最佳地制造定制和复杂的3D组织。