Tissue-specific regulation of nuclear organisation, genome folding, and gene expression

核组织、基因组折叠和基因表达的组织特异性调控

• 批准号: 386298-2010
• 负责人: Mitchell, Jennifer
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528813
• 关键词: Tissue; specific; regulation; nuclear; organisation

Every cell in our bodies contains the same genetic material, but what differentiates a neuron from a muscle cell is the way in which that material is interpreted by the transcriptional machinery responsible for gene expression. The mechanisms by which DNA is packaged into chromatin, epigenetically modified, and folded in the nuclear space all contribute to genome function providing the complexity required for multi-cellular life.

我们体内的每个细胞都含有相同的遗传物质，但神经元与肌肉细胞的区别在于负责基因表达的转录机制对这些物质的解释方式。 DNA被包装到染色质中、表观遗传修饰和在核空间中折叠的机制都有助于基因组功能，提供多细胞生命所需的复杂性。