The role of mediotemporal structures in the interaction of working memory and long-term memory

中颞叶结构在工作记忆和长期记忆相互作用中的作用

• 批准号: 72229919
• 负责人: Privatdozent Dr. Jürgen Fell
• 金额: --
• 依托单位: Beta Klinik GmbH
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/72229919?language=en
• 关键词: role; mediotemporal; structures; interaction; working

Clinical and lesion data, as well as results from imaging and intracranial EEG studies, have shown that mediotemporal lobe (MTL) structures are essential for the initial processes underlying declarative long-term memory (LTM) formation. Our own previous data indicated that in particular synchronization processes between rhinal cortex and hippocampus are crucial for successful LTM formation. Traditionally, MTL structures were thought to specifically support LTM, but not working memory (WM). Recent findings, however, have demonstrated that MTL structures are involved in WM processes as well, in particular, when WM leads to LTM formation. We propose to investigate the interaction between WM and LTM by MTL depth recordings in presurgical epilepsy patients. This approach provides direct information about neural processes in the MTL in humans with a temporal and spatial precision unmatched by other methods. Patients will perform four event-related experiments that comprise both, WM and LTM processing. The aim is to specify EEG characteristics, in particular oscillatory patterns, which accompany correct vs. incorrect WM processing in combination with successful vs. non-successful LTM formation. These data will shed new light on the neural bases and the mechanisms of interaction of WM and LTM.

临床和病变数据，以及成像和颅内EEG研究的结果表明，中颞叶（MTL）结构是必不可少的陈述性长期记忆（LTM）形成的初始过程。我们自己以前的数据表明，特别是鼻皮质和海马之间的同步过程是成功的LTM形成的关键。传统上，MTL结构被认为专门支持LTM，而不是工作记忆（WM）。然而，最近的研究结果表明，MTL结构参与WM过程，特别是当WM导致LTM形成。我们建议在手术前癫痫患者中通过MTL深度记录来研究WM和LTM之间的相互作用。这种方法提供了有关人类MTL中神经过程的直接信息，具有其他方法无法比拟的时间和空间精度。患者将进行四个与事件相关的实验，包括WM和LTM处理。目的是指定EEG特征，特别是振荡模式，其伴随正确与不正确的WM处理，以及成功与不成功的LTM形成。这些数据将为WM和LTM相互作用的神经基础和机制提供新的线索。

项目成果

Using state-trace analysis to dissociate the functions of the human hippocampus and perirhinal cortex in recognition memory

• DOI: 10.1073/pnas.1215710110
• 发表时间: 2013-02-19
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Staresina, Bernhard P.;Fell, Juergen;Henson, Richard N.
• 通讯作者: Henson, Richard N.