The impact of auditory induced synchronization on memory processing

听觉诱发同步对记忆处理的影响

• 批准号: 220533883
• 负责人: Privatdozent Dr. Jürgen Fell
• 金额: --
• 依托单位: Klinik für Epileptologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/220533883?language=en
• 关键词: impact; auditory; induced; synchronization; memory

Previous research indicates that EEG phase synchronization is an important mechanism supporting memory processes. This project aims at investigating whether auditory stimulation increases phase synchronization between mediotemporal and neocortical areas and whether this, in turn, enhances memory performance. For this purpose, monaural and binaural auditory beats with beat frequencies in the range of the dominant EEG rhythms will be applied to presurgical epilepsy patients while recording EEG from intracranial electrodes. In a first step, we will evaluate whether an EEG amplitude increase at the beat frequencies, as well as phase synchronization between different neocortical and mediotemporal areas can be achieved by auditory stimulation and is associated with enhanced memory functions. In a second step, it will be investigated whether formation of dream memories during sleep can be enhanced in epilepsy patients by continuous stimulation with auditory beats. Finally, it will be evaluated whether performance in working and long-term memory tasks can be enhanced in healthy subjects by event-related auditory beat stimulation.

已有研究表明，脑电相同步是支持记忆过程的重要机制。该项目旨在研究听觉刺激是否会增加中颞叶和新皮层区域之间的相同步，以及这是否会反过来提高记忆表现。为此，术前癫痫患者将在颅内电极记录脑电图的同时，对其施加单耳和双耳听觉节拍，其节拍频率在脑电图主要节律范围内。在第一步中，我们将评估听觉刺激是否可以在节拍频率下实现脑电图振幅的增加，以及不同新皮层和中颞叶区域之间的相位同步，并与增强的记忆功能有关。在第二步中，研究人员将研究是否可以通过持续的听觉刺激来增强癫痫患者睡眠中梦记忆的形成。最后，我们将评估事件相关的听觉节拍刺激是否能提高健康受试者在工作和长期记忆任务中的表现。

项目成果

Intracranial electroencephalography power and phase synchronization changes during monaural and binaural beat stimulation

• DOI: 10.1111/ejn.12760
• 发表时间: 2015-01-01
• 期刊: EUROPEAN JOURNAL OF NEUROSCIENCE
• 影响因子: 3.4
• 作者: Becher, Ann-Katrin;Hoehne, Marlene;Fell, Juergen
• 通讯作者: Fell, Juergen

Modulation of long-term memory using auditory beat stimulation

使用听觉节拍刺激调节长期记忆

• DOI: 10.1016/j.brs.2017.01.061
• 发表时间: 2017
• 期刊: Brain Stimulation
• 影响因子: 7.7
• 作者: Chaieb L;Höhne M;Staresina B;Elger CE;Hampel K;Surges R;Fell J
• 通讯作者: Fell J