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Neurophysiological study on the cortical mechanisms of rhythmic waves

节律波皮质机制的神经生理学研究

基本信息

批准号：
59570070
负责人：
OSHIMA Tomokazu
金额：
$ 1.09万
依托单位：
Tokyo Metropolitan Institute for Neurosciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-59570070/
关键词：
Cerebral cortex Thalamic ventrolateral nucleus Cortical motor area Cortical surface stimulation Encephale isole preparation Cat Spindle wave ニューロン活動

项目摘要

The encephale isole cat preparations were carefully maintained in a sound condition with spontaneously alternating sleep-waking phases. By recording the intracellular potentials of motor cortical neurones, we investigated the temporal and spatial patterns of intracortical spread of activities produced by stimulating three input pathways to the cortex that were relevant to generation of various electrocortical rhythmic waves. The responses to the direct cortical surface stimulation started in the most superficial layers with short-latency monosynaptic excitation, and spread horizontally and vertically towards the deep layers, in which long-latency polysynaptic excitation, inhibition, disfacilitation, and disinhibition occurred. These responses were transmitted across laminae in a cascade manner from superficial to deep layers, and were proved to be identical with those induced during the initial phasic phase of electrocortical arousal with the well-known low voltage fast pattern. The responses to the cerebral peduncle stimulation were observed in middle and deep layer cells as excitation, inhibition, or the both combined with the latencies shorter in deep than in middle layer cells. The responses to the ventrolateral thalamic stimulation consisted of excitation, inhibition,or the both, of the latencies shortest in the middle layer with the tendency of prolongation towards both the surface and the depths. Comparison of the responses in respective neurones to the three input stimulations has revealed that the cortical surface and thalamic inputs activate the common neuronal assemblies with the identical response repertoire in contrast to the peduncle input for which the responses are somewhat different from those to the other two inputs. Preliminary examinations were also made on the configuration of electrocortical spindle waves induced spontaneously and by the cortical surface or thalamic stimulation.

将脑隔离猫制剂小心地保持在良好的条件下，具有自发交替的睡眠-觉醒阶段。通过记录运动皮层神经元的细胞内电位，我们研究了刺激三条输入途径到皮层产生的活动在皮层内传播的时间和空间模式，这三条输入途径与各种皮层电节律波的产生有关。对皮层表面直接刺激的反应开始于最表层的短潜伏期单突触兴奋，并向深层水平和垂直传播，其中发生长潜伏期多突触兴奋、抑制、去易化和去抑制。这些反应以级联的方式从浅层到深层跨层传递，并且被证明与在具有众所周知的低电压快速模式的皮层电唤醒的初始相位相期间诱导的那些反应相同。刺激大脑脚后，中、深层细胞均表现为兴奋、抑制或两者兼有，深层细胞的潜伏期短于中层细胞。丘脑腹外侧区刺激的反应包括兴奋，抑制，或两者兼而有之，在中间层的最短的lavelets延长的倾向，向表面和深度。在各自的神经元的三个输入刺激的反应的比较表明，皮层表面和丘脑的输入激活共同的神经元组件与相同的反应剧目相反，脚输入的反应是有些不同的，从其他两个输入。还对自发和皮层表面或丘脑刺激诱发的皮层电梭波的结构进行了初步检查。