Studies on equid herpesvirus 1 infection in mice.

以小鼠为实验对象，研究了马驹疱疹病毒1型（EHV-1）感染的保护性免疫机制、病毒血症发生率及对分娩的影响。实验结果如下：鼻内感染后7天内，CD4或CD8 T细胞亚群均可抑制BALB/cA小鼠肺中EHV-1的生长。肺内病毒生长抑制与肺内TNF活性无显著相关性，提示TNF对EHV-1.3无抗病毒活性。再次感染ehv - 1免疫小鼠发生病毒血症的发生率和持续时间与初次感染相似，但免疫小鼠的病毒在耳内的生长明显受到抑制。抗体是抑制免疫小鼠肺部病毒生长的一种机制。在CB-17酸小鼠中，病毒在肺部的生长很快受到某种非特异性机制的抑制，表明小鼠对EHV-1感染的保护机制尚不充分。妊娠15 ~ 17天的BALB/cA小鼠鼻内感染EHV-1，不仅会导致小鼠出现临床症状，还会导致胎儿发育迟缓和死亡。然而，在任何接受测试的新生儿中都没有发现这种病毒。

Using mice, mechanism of protective immunity, incidence of viremia and effect on parturition were studied in equid herpesvirus 1 (EHV-1) infection. Following results were obtained.1. Growth of EHV-1 in lungs of BALB/cA mice was suppressed by either CD4 or CD8 T cell subset within 7days after intranasal infection.2. There was not significant correlation between suppression of virus growth in lung and TNF activity in lung, indicating no anti-viral activity of TNF against EHV-1.3. Viremia occurred in reinfection of EHV-l-immunized mice as similar incidence and duration to initial infection, although growth of the virus in lugs of immunized mice was markedly suppressed.4. As a mechanism of suppression of viral growth in lungs of immunized mice, antibody was indicated.5. Jn CB-17 acid mice, viral growth in lungs was quickly suppressed by a certain non-specific mechanism, indicating inadequate mice for analyzing protective mechanism against EHV-1 infection.6. Intranasal infection with EHV-1 in pregnant BALB/cA mice at 15 to 17 days of gestation resulted in not only clinical signs in dams, but also growth retardation and death of fetuses. However, the virus could not be demonstrated in any neonates tested.