Immunological prevention of age-related hearing loss : analysis of its molecular biological mechanisms

年龄相关性听力损失的免疫预防：分子生物学机制分析

• 批准号: 21592170
• 负责人: IWAI Hiroshi
• 金额: $ 2.83万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592170/
• 关键词: 老人性難聴; 免疫老化; IL-1R2; CD4^+T細胞; 胎児胸腺; Treg; 浸透圧ポンプ; CD4+T細胞; IL-7; KGF; ヘルパーT細胞; 移植; up regulation; 加齢; interleukin 1 receptor types II; 胸腺; 遺伝子; mRNA

We found that rejuvenation of the recipient immunity by inoculation of young CD4^+T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II(IL-1R2) gene in CD4^+T cells and reduced age-related hearing loss in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.

我们发现，通过接种年轻的CD 4 ^+T细胞或胎儿胸腺移植物来恢复受体免疫力，可以下调CD 4 ^+T细胞中的白细胞介素1受体II型（IL-1 R2）基因，并减少SAMP 1小鼠（一种人类衰老的小鼠模型）中与年龄相关的听力损失。我们对年龄相关的系统性免疫功能障碍和神经退行性变机制之间关系的研究为治疗神经衰老开辟了新的途径，包括老年性耳聋，对此没有有效的治疗方法。

项目成果

Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4+ T cells

• DOI: 10.1016/j.jneuroim.2012.05.007
• 发表时间: 2012-09-15
• 期刊: JOURNAL OF NEUROIMMUNOLOGY
• 影响因子: 3.3
• 作者: Iwai, Hiroshi;Inaba, Muneo
• 通讯作者: Inaba, Muneo

tal Thymus Graft Prevents Presbycusis and Age-Related Up Regulation of The IL-1 Receptor Type II Gene in Th cell

总胸腺移植物预防老年性耳聋和 Th 细胞中 IL-1 受体 II 型基因与年龄相关的上调

• 发表时间: 2011
• 作者: Iwai H;Inaba M;Baba S;Tomoda K
• 通讯作者: Tomoda K

Inoculation of helper T cells as a strategy for the prevention of age-related hearing loss in SAMP1 mice

接种辅助 T 细胞作为预防 SAMP1 小鼠年龄相关性听力损失的策略

• 发表时间: 2009
• 作者: Iwai H;Baba;Inaba M;Sakaguchi M;Lee S;Ikehara S;Tomoda K
• 通讯作者: Tomoda K

T細胞機能維持による進行性老人性難聴予防

通过维持 T 细胞功能预防进行性老年性耳聋

• 发表时间: 2009
• 作者: 岩井大;坂口麻理子;馬場奨;李進隆;友田幸一
• 通讯作者: 友田幸一

Amelioration of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells

免疫调节树突状细胞改善2,4,6-三硝基苯磺酸诱导的小鼠结肠炎

• 发表时间: 2011
• 期刊: J. Gastroenterol
• 作者: Hoshino S.;Kurishima A.;Inaba M.;Ando Y.;Fukui T.;Uchida K.;Nishio A.;Iwai H.;Yokoi T.;Ito T.;Hasegawa-Ishii S.;Shimada A.;M. Li;K. Okazaki;S. Ikehara
• 通讯作者: S. Ikehara