New Functional Metal-Organic Frameworks for (Enantio)selective Catalysis and Separation

有限的自然资源和对对映体纯化合物日益增长的需求使得催化，特别是不对称催化成为一项关键技术。虽然非对称催化领域长期以来一直由均相催化剂主导，因为它具有优异的选择性和活性，但非均相催化剂可以提供比易于分离或回收更多的东西。研究表明，该催化剂的活性和选择性优于均相催化剂，并可采用新颖、高效的反应机理来解决剩余的合成问题。该联盟在第一阶段证明了手性mof的模块化从头构建是整合催化活性（手性）功能的理想选择。为了提高不对称催化中的对映选择性，并利用已有的原理证明手性分离，有机化学家（手性连接体合成），无机化学家（MOF合成），分析化学家（核磁共振表征）和技术化学家（色谱分离）将提供所需的互补专业知识，通过对底物的强相互作用的合理整合来证明高对映体选择性。在该项目的第二阶段，该财团将测试MOFs在更广泛的分离应用和精细化学品催化转化中的适用性。

Limited natural resources and an increasing demand for enantiomerically pure compounds render catalysis, and especially asymmetric catalysis, to be a key technology. Although the field of asymmetric catalysis has been dominated for a long time by homogeneous catalysis because of the excellent selectivity and activity obtained, heterogeneous catalysts can offer even more than facile separation or recycling. It has been shown that activity and selectivity comparing favourably with homogeneous catalysts can be obtained and novel, efficient reaction mechanisms can be employed to solve remaining synthetic problems.The modular de novo construction of chiral MOFs was demonstrated by the consortium in the first phase to be ideal for the integration of catalytically active (chiral) functions. In order to enhance the enantioselectivity in asymmetric catalysis and demonstrate chiral separation using the principles developed so far, an interdisciplinary cooperation between organic chemists (chiral linker synthesis), inorganic chemists (MOF synthesis), analytic chemists (NMR characterization) and technical chemists (chromatographic separation) will provide the complementary expertise needed to demonstrate high enantioselectivity by the rational integration of strong interactions towards the substrate. In the second phase of the project, the consortium will test the applicability of the MOFs achieved in a wider range of separation applications and catalytic transformation of fine chemicals.