New Functional Metal-Organic Frameworks for (Enantio)selective Catalysis and Separation

有限的自然资源和对映体纯化合物需求的增加使得催化，特别是不对称催化，成为关键技术。虽然由于具有优异的选择性和活性，均相催化剂在不对称催化领域长期占据主导地位，但非均相催化剂可以提供比简单的分离或回收更好的选择性和活性。它已被证明，活性和选择性相媲美的均相催化剂，可以获得新的，有效的反应机制，可以用来解决剩余的合成problems.The模块从头构建的手性MOFs被证明是理想的财团在第一阶段的催化活性（手性）功能的整合。为了提高不对称催化反应的对映选择性，并利用迄今发展的原理进行手性分离，有机化学家之间的跨学科合作，（手性连接体合成），无机化学家（M0F合成），分析化学家（NMR表征）和技术化学家（色谱分离）将提供所需的补充专业知识，通过合理整合对底物的强相互作用来证明高对映体选择性。在项目的第二阶段，该联盟将测试MOFs在更广泛的分离应用和精细化学品催化转化中的适用性。

Limited natural resources and an increasing demand for enantiomerically pure compounds render catalysis, and especially asymmetric catalysis, to be a key technology. Although the field of asymmetric catalysis has been dominated for a long time by homogeneous catalysis because of the excellent selectivity and activity obtained, heterogeneous catalysts can offer even more than facile separation or recycling. It has been shown that activity and selectivity comparing favourably with homogeneous catalysts can be obtained and novel, efficient reaction mechanisms can be employed to solve remaining synthetic problems.The modular de novo construction of chiral MOFs was demonstrated by the consortium in the first phase to be ideal for the integration of catalytically active (chiral) functions. In order to enhance the enantioselectivity in asymmetric catalysis and demonstrate chiral separation using the principles developed so far, an interdisciplinary cooperation between organic chemists (chiral linker synthesis), inorganic chemists (MOF synthesis), analytic chemists (NMR characterization) and technical chemists (chromatographic separation) will provide the complementary expertise needed to demonstrate high enantioselectivity by the rational integration of strong interactions towards the substrate. In the second phase of the project, the consortium will test the applicability of the MOFs achieved in a wider range of separation applications and catalytic transformation of fine chemicals.