Development and characterization of MOF based chromatographic materials combining size exclusion, intrinsic chirality and specific interactions

基于MOF的新型尺寸排除层析材料的设计与探索。该项目旨在利用MOF尖锐的孔径分布，填补沸石和硅基材料之间的尺寸差距。由于有机连接物的多样性，这一特性与MOF网络设计中的非凡灵活性相结合，将被用于根据几何形状、吸附强度和手性产生特定的分析物晶格相互作用环境。这与现有材料不同，现有材料的改性通常是通过在材料上附着相当大的有机单元来实现的，这些有机单元主要填充在孔隙中，从而在尺寸排除和吸附层析之间造成了一定的区分。在该项目中，基于乙炔的连接物将被用作细长但坚硬的结构单元，以形成易于接近和大孔的网络结构。除了其他相互作用外，这些连接体还将允许通过C-H/π接触解决涉及软酸的特定分离问题。乙炔基团与基于羧酸锌的SBUS相结合允许独立地选择用于网络形成的SBU和连接物的类型。将进行层析实验以评估生成的材料并将其与现有材料进行比较。

Design and exploration of new MOF based size exclusion chromatography materials. The project aims at the utilization of the sharp pore size distribution of MOFs filling the size gap between zeolite and silica based materials. This feature in combination with the extraordinary flexibility in MOF network design, due to the variability of the organic linkers, will be used to generate, as part of the backbone, specific analyte lattice interaction environments based on geometry, adsorptive strength, and chirality. This is in contrast to existing materials, where modification are usually implemented by attaching rather spacious organic units to the material filling largely the pores and thus causing a certain division between size exclusion and adsorption chromatography. Within the project, acetylene based linkers will be used as slim but rigid structural units to form network structures with easily accessible and large pores. Besides other interactions, these linkers will also allow to address specific separation problems involving soft acids via C-H/π contacts. The acetylene group in combination with zinc carboxylate based SBUs permits to select independently the type of SBU and linker for the network formation. Chromatographic experiments will be carried out to evaluate the generated materials and to compare them to existing ones.