Development and characterization of MOF based chromatographic materials combining size exclusion, intrinsic chirality and specific interactions

新型MOF阻粒径色谱材料的设计与探索。该项目旨在利用mof的尖锐孔径分布来填补沸石和二氧化硅基材料之间的尺寸差距。由于有机连接物的可变性，这一特性与MOF网络设计的非凡灵活性相结合，将用于生成作为主干的一部分，基于几何形状、吸附强度和手性的特定分析物晶格相互作用环境。这与现有的材料形成对比，在现有的材料中，通常通过将相当宽敞的有机单元附着在主要填充孔隙的材料上来实现改性，从而在尺寸排除和吸附色谱之间产生一定的区分。在该项目中，基于乙炔的连接件将被用作细长但刚性的结构单元，形成易于接近和大孔隙的网络结构。除了其他相互作用外，这些连接剂还可以通过C-H/π接触解决涉及软酸的特定分离问题。乙炔基团与羧酸锌基SBU结合，可以独立选择SBU的类型和网络形成的连接剂。将进行色谱实验来评价生成的材料，并将其与现有材料进行比较。

Design and exploration of new MOF based size exclusion chromatography materials. The project aims at the utilization of the sharp pore size distribution of MOFs filling the size gap between zeolite and silica based materials. This feature in combination with the extraordinary flexibility in MOF network design, due to the variability of the organic linkers, will be used to generate, as part of the backbone, specific analyte lattice interaction environments based on geometry, adsorptive strength, and chirality. This is in contrast to existing materials, where modification are usually implemented by attaching rather spacious organic units to the material filling largely the pores and thus causing a certain division between size exclusion and adsorption chromatography. Within the project, acetylene based linkers will be used as slim but rigid structural units to form network structures with easily accessible and large pores. Besides other interactions, these linkers will also allow to address specific separation problems involving soft acids via C-H/π contacts. The acetylene group in combination with zinc carboxylate based SBUs permits to select independently the type of SBU and linker for the network formation. Chromatographic experiments will be carried out to evaluate the generated materials and to compare them to existing ones.