Development and characterization of MOF based chromatographic materials combining size exclusion, intrinsic chirality and specific interactions

新型多功能分子排阻色谱材料的设计与开发。该项目旨在利用MOFs的尖锐孔径分布，填补沸石和硅基材料之间的尺寸差距。由于有机连接体的可变性，该特征与MOF网络设计中的非凡灵活性相结合，将用于生成作为骨架的一部分的基于几何形状、吸附强度和手性的特定分析物晶格相互作用环境。这与现有材料相反，现有材料的改性通常通过将相当大的有机单元附着到材料上来实现，从而填充大量的孔，从而在尺寸排阻和吸附色谱之间造成一定的划分。在该项目中，乙炔基连接剂将用作细长但刚性的结构单元，以形成具有容易接近和大孔的网络结构。除了其他相互作用之外，这些连接体还将允许通过C-H/π接触解决涉及软酸的特定分离问题。乙炔基团与基于羧酸锌的SBU组合允许独立地选择SBU和连接体的类型以形成网络。将进行色谱实验以评价生成的材料并将其与现有材料进行比较。

Design and exploration of new MOF based size exclusion chromatography materials. The project aims at the utilization of the sharp pore size distribution of MOFs filling the size gap between zeolite and silica based materials. This feature in combination with the extraordinary flexibility in MOF network design, due to the variability of the organic linkers, will be used to generate, as part of the backbone, specific analyte lattice interaction environments based on geometry, adsorptive strength, and chirality. This is in contrast to existing materials, where modification are usually implemented by attaching rather spacious organic units to the material filling largely the pores and thus causing a certain division between size exclusion and adsorption chromatography. Within the project, acetylene based linkers will be used as slim but rigid structural units to form network structures with easily accessible and large pores. Besides other interactions, these linkers will also allow to address specific separation problems involving soft acids via C-H/π contacts. The acetylene group in combination with zinc carboxylate based SBUs permits to select independently the type of SBU and linker for the network formation. Chromatographic experiments will be carried out to evaluate the generated materials and to compare them to existing ones.