Effects of Hypercholesterolemic Diet and Occlusal Trauma on the Mandible of Osteoporotic Rats

高胆固醇饮食和咬合创伤对骨质疏松大鼠下颌骨的影响

• 批准号: 09672029
• 负责人: HIDAKA Saburo
• 金额: $ 0.7万
• 依托单位: Fukuoka College of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672029/
• 关键词: Osteoporosis; Amargam filling; Hypercholesterolemic diet; Mandible; Occlusal Trauma; Rats; Artericsclerosis; 骨密度

Effects of oodusalstress (OS) on both the periodontium and the tibia in ovariectomized rats fed with hypercholesterolemic diet (HC) were studied Alter fifteen-week feeding the tibial bone mineml density (BMD) in ovariectomized (OVX) rats decreased by 27% from that in sham-operated (sham) rats. But, there were no effects by HC diet and OS on the BMD.The bcne mineral content (BMC) of the mandibular candyle in OVX rats was similar to Sham rats. Also, there were ro effect by HO and OS.However the scanniing electron microsopic (SEM) ana1yses revealed that the periodontal ligament of the OVX rats and the OVX rats given OS became more coarse than that of the Sham rats or the rat treated with 17 beta-estradiol. The surface of the alveolar bone in the OVX rats appeared to contain numerous small granules, whichh were not present in the Sham rats and the rats treated with 17 beta-estradio1. Thus, it was found that * caused alterations in the periodontium and the surface architecture of the alveolarbones. These results suggest that the OS may affect to deterirate the peridontal a1terations and the HC diet may affect to delay the recovery.

用高胆固醇饮食(HC)喂养去卵巢大鼠15周，观察了应激(OS)对去卵巢大鼠胫骨骨密度(BMD)较假手术组(Sham)降低27%的影响。去卵巢大鼠下颌骨烛状突骨矿物质含量(BMC)与假手术组相似。扫描电子显微镜(SEM)分析显示，OVX组和OVX组大鼠牙周膜较假手术组和17β-雌二醇组大鼠的牙周膜变粗。卵巢切除组大鼠牙槽骨表面可见大量小颗粒，而假手术组和17β-雌激素组大鼠牙槽骨表面未见小颗粒。因此，研究发现*会引起牙周组织和牙槽骨表面结构的改变。这些结果表明，OS可能影响阻止牙周改变，而HC饮食可能影响牙周组织的恢复。

项目成果

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