Effects of Hypercholesterolemic Diet and Occlusal Trauma on the Mandible of Osteoporotic Rats

本文观察了高胆固醇饮食（HC）对去卵巢大鼠牙周组织和胫骨骨密度的影响。15周后，去卵巢（OVX）大鼠胫骨骨密度（BMD）较假手术（sham）大鼠降低27%。但HC饮食和OS对骨密度无明显影响，OVX大鼠下颌骨的骨矿物质含量（BMC）与Sham大鼠相似。但扫描电镜分析显示，OVX组和OS组大鼠牙周膜较Sham组和17 β-雌二醇组大鼠粗糙。OVX大鼠的牙槽骨表面似乎含有许多小颗粒，而Sham大鼠和17 β-雌二醇治疗的大鼠中不存在这些颗粒。因此，发现 * 引起牙周组织和牙槽骨表面结构的改变。结果提示，OS可能影响围手术期的恢复，HC饮食可能影响延迟恢复。

Effects of oodusalstress (OS) on both the periodontium and the tibia in ovariectomized rats fed with hypercholesterolemic diet (HC) were studied Alter fifteen-week feeding the tibial bone mineml density (BMD) in ovariectomized (OVX) rats decreased by 27% from that in sham-operated (sham) rats. But, there were no effects by HC diet and OS on the BMD.The bcne mineral content (BMC) of the mandibular candyle in OVX rats was similar to Sham rats. Also, there were ro effect by HO and OS.However the scanniing electron microsopic (SEM) ana1yses revealed that the periodontal ligament of the OVX rats and the OVX rats given OS became more coarse than that of the Sham rats or the rat treated with 17 beta-estradiol. The surface of the alveolar bone in the OVX rats appeared to contain numerous small granules, whichh were not present in the Sham rats and the rats treated with 17 beta-estradio1. Thus, it was found that * caused alterations in the periodontium and the surface architecture of the alveolarbones. These results suggest that the OS may affect to deterirate the peridontal a1terations and the HC diet may affect to delay the recovery.