Novel synthesis of indole derivatives based on the palladium catalyzed cross-coupling reaction with indolylborates as a key reaction

吲哚基硼酸酯，容易从相应的2-锂吲哚和三乙基硼烷原位，是有价值的合成中间体，和他们的合成能力的发展一直是我们的持续兴趣。在这些研究中，钯催化的吲哚硼酸酯的交叉偶联反应已被证明是制备取代吲哚衍生物的有效方案。在这些研究中，通过使用交叉偶联反应作为关键反应，取得了以下成果：1。钯催化串联环化偶联反应合成椭圆藤碱及其类似物2。钯催化的羰基交叉偶联反应合成越竹烯及其类似物。

Indolylborates, readily available from the corresponding 2-lithioindoles and triethylborane in situ, are valuable synthetic intermediates, and the development of their synthetic capabilities has been our continuing interest. During these studies, the palladium catalyzed cross-coupling reaction with indolylborates has been proven to be an effective protocol for the preparation of substituted indole derivatives. In these studies, the followings have been achieved by the use of the cross-coupling reaction as a key reaction;1. Synthesis of ellipticine and its analogues by the palladium catalyzed tandem cyclization cross-coupling reaction2. Synthesis of yuehchukene and its analogues by the palladium catalyzed carbonylative cross-coupling reaction.