Novel synthesis of indole derivatives based on the palladium catalyzed cross-coupling reaction with indolylborates as a key reaction

吲哚基硼酸酯是一种很有价值的合成中间体，其合成能力的开发一直是我们一直关注的问题。在这些研究中，钯催化的与吲哚基硼酸酯的交叉偶联反应已被证明是制备取代吲哚衍生物的一种有效方法。在这些研究中，以交叉偶联反应为关键反应完成了以下工作：1.钯催化串联环化交叉偶联反应合成椭圆碱及其类似物。钯催化的羰基化交叉偶联反应合成月桂烯及其类似物。

Indolylborates, readily available from the corresponding 2-lithioindoles and triethylborane in situ, are valuable synthetic intermediates, and the development of their synthetic capabilities has been our continuing interest. During these studies, the palladium catalyzed cross-coupling reaction with indolylborates has been proven to be an effective protocol for the preparation of substituted indole derivatives. In these studies, the followings have been achieved by the use of the cross-coupling reaction as a key reaction;1. Synthesis of ellipticine and its analogues by the palladium catalyzed tandem cyclization cross-coupling reaction2. Synthesis of yuehchukene and its analogues by the palladium catalyzed carbonylative cross-coupling reaction.