Expression and Function of IHRP

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The mouse counterpart of human IHRP has been partially purified from mouse serum, and the cDNA come encoding this protein was isolated and characterized. The amino acid sequence of mouse IHRP predicted from the nucleotide sequence of cDNA shows reasonable homology to those of human and pig IHRP.The N-terminal amino acid sequence of partially purified mouse IHRP was completely matched to that predicted from its cDNA.The expression of IHRP in mouse was induced by treatment with turpentine oil or LPS.The induction of IHRP by turpentine was effectively prevented by pretreatment with dexamethasone, but the induction by LPS was not- affected by dexamethasone.