Effect of daity physical activity, bone mineral density, muscle thickness and urinary free-deoxypyridinoline on the prevention of fractures in middle-aged and elderly women.

本研究的目的是检查日常体力活动，肌肉厚度和尿中游离脱氧吡啶啉（free-Dpyr）的排泄量对骨密度（BMD）和预防骨折的中老年妇女的影响。在这些横断面和纵向研究中，我们使用Hologic的QDR-1500双X线骨密度仪测量腰椎和股骨的BMD，使用Osteon的Osteoanalyzer单X线骨密度仪测量跟骨的BMD，使用超声和尿中游离Dpyr排泄（ELISA法）测量股骨肌厚度。此外，我们还评估了健康中年和老年妇女的BMD和日常体力活动之间的关系。获得了以下结果。1997年腰椎、跟骨和股骨BMD与年龄呈负相关。尤其是跟骨、股骨颈和沃德三角区的相关性显著。股肌厚度与年龄呈显著负相关。1998年，BMD和肌肉厚度在1年内的变化显着下降。然而，游离Dpyr的值略高于初始值。此外，经常锻炼的受试者的BMD显著高于不经常锻炼的受试者。结果表明，将BMD和骨吸收标志物（游离Dpyr）的测量结合起来，除了建立每日体力活动量和促进肌肉质量外，还有助于改善对女性骨健康和骨折风险的评估。此外，体力活动和锻炼可能是防止肌肉质量和力量损失的重要因素。

The purpose of this study was to examine the effect of daily physical activity, muscle thickness and urinary excretion of free-deoxypyridinoline (free-Dpyr) on bone mineral density (BMD) and the prevention of fracture in middle-aged and elderly women. In these cross-sectional and longitudinal studies, we measured the BMD in the lumbar spine and the femur using dual X-ray absorptiometry with Hologic's QDR-1500 and that in the calcaneus using single X-ray absorptiometry with Osteon's Osteoanalyzer and the femoral muscle thickness using ultrasonography and urinary excretion of free-Dpyr (ELISAmethod). In addition, we evaluated the relationship between BMD and daily physical activity in healthy middle-aged and elderly women. The following results wereobtained. In 1997, the BMD in the lumbar spine, the calcaneus and the femur showed a negative correlation with age. In particular, those in the calcaneus, the femoral neck and ward's triangle showed significant correlations. Moreover, the femoral muscle thickness showed a significant negative correlation with age. In 1998, the change in the BMD and muscle thickness over a 1-year period was significantly decreased. However, values of free-Dpyr were slightly higher than those of the initial value. In addition, subjects who exercised regularly had significantly higher BMD than those who did not.The results suggested that combining the measurement of BMD and bone resorptionmarker (free-Dpyr), in addition to establishing daily physical activity routinesand promoting muscle mass, are useful to improve the assessment of bone health and the risk of fracture in women. Moreover, physical activity and exercise may beimportant factors in preventing loss of muscle mass and strength.