Dissipative Supramolecular Reactor

我们新的全氟冠醚官能化合成策略在各个领域都有潜在的应用前景。战略设计的冠醚衍生物在熔融状态下形成强大的超分子聚合物，具有高粘合强度和韧性，这归因于动态氢键和氟-氟相互作用。这种材料在水下和聚四氟乙烯薄片上表现出优异的粘附性，使其成为传统粘合聚合物的潜在替代品。此外，冠醚衍生物与水团簇表现出强烈的相互作用，使它们能够快速穿透细胞膜。而相应的非氟类似物在长时间孵育后仍不能穿透膜双层，适合药物化学和药物释放。

Our novel synthetic strategy for functionalizing perfluoro crown ethers has potential applications in various fields. Strategically designed crown ether derivatives form strong supramolecular polymers in the molten state with high adhesive strength and toughness, attributed to dynamic hydrogen bonding and Fluorine-Fluorine interactions. This material shows excellent underwater and PTFE sheet adhesion, making it a potential replacement for conventional adhesive polymers. Additionally, crown ether derivatives exhibit strong interactions with water clusters, allowing them to penetrate cell membranes quickly. Whereas the corresponding nonfluorinated analog failed to penetrate the membrane bilayer even after prolonged incubation, making them suitable for medicinal chemistry and drug delivery.