Dissipative Supramolecular Reactor

我们的全氟冠醚功能化的新合成策略在各个领域具有潜在的应用。策略性设计的冠醚衍生物在熔融状态下形成具有高粘合强度和韧性的强超分子聚合物，这归因于动态氢键和氟-氟相互作用。这种材料具有优异的水下和PTFE片材粘合性，使其成为传统粘合剂聚合物的潜在替代品。此外，冠醚衍生物表现出与水簇的强相互作用，使它们能够快速穿透细胞膜。而相应的非氟化类似物即使在长时间孵育后也未能穿透膜双层，使其适合于药物化学和药物递送。

Our novel synthetic strategy for functionalizing perfluoro crown ethers has potential applications in various fields. Strategically designed crown ether derivatives form strong supramolecular polymers in the molten state with high adhesive strength and toughness, attributed to dynamic hydrogen bonding and Fluorine-Fluorine interactions. This material shows excellent underwater and PTFE sheet adhesion, making it a potential replacement for conventional adhesive polymers. Additionally, crown ether derivatives exhibit strong interactions with water clusters, allowing them to penetrate cell membranes quickly. Whereas the corresponding nonfluorinated analog failed to penetrate the membrane bilayer even after prolonged incubation, making them suitable for medicinal chemistry and drug delivery.