Understanding, Predicting and Preventing Type 2 Diabetes in Youth, Boston Clinical Center (UPP Study)

了解、预测和预防青少年 2 型糖尿病,波士顿临床中心(UPP 研究)

基本信息

  • 批准号:
    10583740
  • 负责人:
  • 金额:
    $ 16.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-10 至 2029-01-31
  • 项目状态:
    未结题

项目摘要

Project Summary / Abstract Rising obesity has led to an unprecedented increase in pre-diabetes (preD) and type 2 diabetes (T2D) incidence in children and adolescents, a worrisome trend amplified by the COVID 19 pandemic. Based on current evidence, it remains difficult to predict whether children and adolescents with preD will progress to T2D. Our proposal aims to address key questions in the pathogenesis of T2D, focusing on modifiable risk factors. Leveraging a collaboration between Boston Children’s Hospital, Joslin Diabetes Center, and Massachusetts General Hospital, in partnership with community health centers in the Greater Boston area, we propose to recruit a diverse cohort of early pubertal youth (ages 7-15, n=300) with preD, elevated BMI (≥95th percentile), a positive family history of diabetes, and one or more additional risk factors. We propose to combine rigorous annual clinical studies with convenient remote assessments, to gain a granular understanding of metabolic, hormonal and environmental factors contributing to T2D pathogenesis. In Aim 1, we will test whether measures of glucose homeostasis and beta cell function differ between youth with preD who progress to T2D versus those who revert to normoglycemia or remain preD. We propose to analyze glycemia and beta cell function using oral GTT and incretin hormone levels, and assessments adaptable to community settings, e.g., continuous glucose monitors and home A1c kits. In Aim 2, we will test whether fitness level and amount of physical activity differ between youth with preD who progress to T2D versus those who revert to normoglycemia or remain preD. We propose to evaluate fitness level using detailed clinical assessments, including VO2 max, assessments adaptable to community settings including grip strength, and free-living assessments using wearables and app-based activity tracking. In Aim 3, we will test whether evolution of body composition during growth and puberty predicts progression to T2D. We propose to analyze body composition (total and visceral fat) using DXA, and hepatic fat using echography-based assessments, gonadal hormones, adrenal androgens, and mediators of growth hormone action, as well as assessments adaptable to community settings, e.g., BMI and app-based dietary surveys. As secondary aims, we propose to create a data repository to allow evaluation of social and environmental factors contributing to T2D onset at a consortium level, with measures including social determinants of health, neighborhood and geographic characteristics (using geocoding techniques), and the environmental exposome. We also propose the creation of a biological repository to allow multi-omics studies to identify genomic, epigenetic, and/or metabolomic markers for progression from preD to T2D in youth at a consortium level. We propose to collect a rich biorepository of longitudinal samples (i.e., plasma, PBMCs, urine, stool, hair) from all participants that will set the stage for future systems biology-driven studies. Together, these studies will permit development of a predictive model based on variables easily measurable at the community level, which can then be applied to the detection and treatment of youth at highest risk of T2D.
项目摘要/摘要

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Amy Debra Fleischman其他文献

Amy Debra Fleischman的其他文献

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{{ truncateString('Amy Debra Fleischman', 18)}}的其他基金

Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric Obesity
强化运动可改善儿童肥胖症的线粒体功能障碍
  • 批准号:
    7841930
  • 财政年份:
    2009
  • 资助金额:
    $ 16.68万
  • 项目类别:
Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric Obesity
强化运动可改善儿童肥胖症的线粒体功能障碍
  • 批准号:
    7707756
  • 财政年份:
    2009
  • 资助金额:
    $ 16.68万
  • 项目类别:
MITOCHONDRIAL FUNCTION IN PEDIATRIC OBESITY
小儿肥胖症的线粒体功能
  • 批准号:
    7731335
  • 财政年份:
    2008
  • 资助金额:
    $ 16.68万
  • 项目类别:
Mitochondrial Function in Pediatric Obesity
小儿肥胖中的线粒体功能
  • 批准号:
    7874695
  • 财政年份:
    2007
  • 资助金额:
    $ 16.68万
  • 项目类别:
Mitochondrial Function in Pediatric Obesity
小儿肥胖中的线粒体功能
  • 批准号:
    7622621
  • 财政年份:
    2007
  • 资助金额:
    $ 16.68万
  • 项目类别:
Mitochondrial Function in Pediatric Obesity
小儿肥胖中的线粒体功能
  • 批准号:
    7471500
  • 财政年份:
    2007
  • 资助金额:
    $ 16.68万
  • 项目类别:
EVALUATION OF GLUCOSE METABOLISM, BONE HEALTH & OVARIAN CONGENITAL ADRENAL
葡萄糖代谢、骨骼健康的评估
  • 批准号:
    7380750
  • 财政年份:
    2006
  • 资助金额:
    $ 16.68万
  • 项目类别:
EVALUATION OF GLUCOSE METABOLISM, BONE HEALTH & OVARIAN CONGENITAL ADRENAL
葡萄糖代谢、骨骼健康的评估
  • 批准号:
    7204734
  • 财政年份:
    2005
  • 资助金额:
    $ 16.68万
  • 项目类别:

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