The mechanism of primary-active transporters, light-driven ion channels and pumps studied by solid-state NMR (P06)

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For translocating substrates across membranes, transport proteins undergo conformational changes at different times and length scales and often require long-range communication between distant domains. Their function is closely coupled to the membrane environment. We will address the interplay of structure, function and dynamics within the lipid bilayer by applying solid-state NMR methods and biochemical approaches to proteins from the ABC transporter and retinal binding protein families.