Effect of sex hormone on oxalate synthesizing enzyme in male and female rat livers.

性激素对雄性和雌性大鼠肝脏草酸合成酶的影响。

• 批准号: 09671599
• 负责人: YACHIKU Sunao
• 金额: $ 1.66万
• 依托单位: Asahikawa medical college
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671599/
• 关键词: oxalate metabolism; enzymes; sex hormone; ethylene glycol; urinary calculi; テストステロン; エチレングルコール; ラット; エストロゲン; シュウ酸カルシウム

Ethylene glycol and glycolate increased urinary oxalate concentration in male rats dose-dependently but less in female rats. There was almost no change during glycine loading in either male or female rats. GO activity was significantly lower in intact female and gonadectomized male rats. SPT activity was slightly higher in the female than in the male controls. There were no differences in urinary oxalate excretions between male and female rats. During ethylene glycol loading, GO and SPT activities were similar to those with tap water intake. However, urinary oxalate excretion increased to two times the control value in male rats but only slightly increased in female rats. Sex-related differences exist in the metabolic conversion of glycolate to oxalate in rats, and GO activity is promoted by testosterone. Although difference in GO activity has no physiological effect on oxalate synthesis, GO activity affects urinary oxalate excretion during ethylene glycol loading. We could also conclude that estrogen decreases GO activity in male rats from our results.

乙二醇和乙醇酸盐剂量依赖性地增加雄性大鼠的尿草酸浓度，但在雌性大鼠中较少。在雄性或雌性大鼠中，甘氨酸负荷期间几乎没有变化。GO活性在完整的雌性和性腺切除的雄性大鼠中显着降低。SPT活性略高于在男性对照组中的女性。雄性和雌性大鼠尿草酸排泄量无差异。在乙二醇负荷期间，GO和SPT活性与自来水摄入相似。然而，雄性大鼠的尿草酸排泄量增加至对照值的两倍，但雌性大鼠仅略有增加。大鼠乙醇酸向草酸的代谢转化存在性别差异，GO活性受睾酮的促进。虽然GO活性的差异对草酸合成没有生理影响，但GO活性影响乙二醇负荷期间尿草酸的排泄。我们还可以得出结论，雌激素降低GO活性在雄性大鼠从我们的结果。

项目成果

山口聡、八竹直: "腎・尿管結石" 総合臨床. 46・増. 499-504 (1997)

Satoshi Yamaguchi，Nao Yatake：“肾/输尿管结石”一般临床实践 46，放大版 499-504 (1997)。

森川満、八竹直他: "尿路結石症における男女差の検討" 日本泌尿器科学会雑誌. 89・5. 538-545 (1998)

Mitsuru Morikawa、Nao Yatake 等：“尿石症的性别差异检查”日本泌尿外科协会杂志 89・5（1998 年）。

Hideki Yoshihara, Sunao Yachiku et.al.: "Effect of sex hormone on oxalate-synthesizing enzymes in male and female rat livers." Journal of Urology.161(2). 668-673 (1999)

Hideki Yoshihara、Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏草酸合成酶的影响。”

Hideki Yoshihara,Sunao Yachiku et al: "Effect of sexhormone on oxalate-synthesizing enzymes in male and female rat livers" Journal of Urology. 161・2. 668-673 (1999)

Hideki Yoshihara、Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏草酸合成酶的影响”泌尿学杂志 161・2（1999）。

Hideki Yoshihara Sunao Yachiku et.al: "Effect of sex hormone on oxalafe-synthesizing enzymes in male and female rat livers" Journal of Urology. 161・2. 668-673 (1999)

Hideki Yoshihara Sunao Yachiku 等人：“性激素对雄性和雌性大鼠肝脏中草酸合成酶的影响”泌尿学杂志 161・2（1999）。