EFFECTS OF OVARIAN STEROIDS ON THE INHIBITION OF ATHEROSCLEROSIS IN RELATION TO THE EFFECTS ON ENDOMETRIUM

卵巢类固醇抑制动脉粥样硬化的作用与对子宫内膜的影响

• 批准号: 09671693
• 负责人: NOZAKI Masahiro
• 金额: $ 2.05万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671693/
• 关键词: ESTROGEN; PROGESTERONE; ATHEROSCLEROSIS; ENDOMETRIUM; 動脈硬化; 子宮内膜作用; 卵巣英ステロイド; エストロゲン; プロゲステロン; 卵巣性ステロイド

It is known that estrogen inhibits the development of atherosclerosis through the effects on lipid metabolism and the action on the vascular function. In the present study, how the ovarian steroids, estrogen and progesterone, act on the vascular wall and endometrium. Albino rabbits, six months old, were divided into six groups ; C (Sham operation), OVX (oophorectomy), OVX+E (estradiol valerate ; 5mg/body/2weeks), OVX+E+1.0P (17 alpha-hydroxyprogesterone capronate ; 125mg/body/2weeks), OVX+E+0.3P, Ovx+E+0.1P. These rabbits were provided the commercial fodder containing 0.5% cholesterol and given those steroids every two weeks. They were terminated after six months and the specimen were made for microscope and tension recording. The thickness of media of thoracic aorta was 844±78μm in OVX ; 2.5 fold thicker than that in non-cholesterol fodder. The order was as follows ; OVX>OVX+E+1.0P>OVX+E+0.3P>OVX+E+0.1P>OVX+E>C. The endothelium-dependent relaxation was smaller in the same order as above. On the other hand, there were no significant differences in those rabbits of the different concentrations of progesterone. It seemed that those concentrations and the number of subjects should be considered. In conclusion, estrogen enhanced relaxation even in the atherosclerotic vessels and progesterone reduced the inhibition of median hyper trophy by estrogen.

已知雌激素通过对脂质代谢的影响和对血管功能的作用来抑制动脉粥样硬化的发展。在本研究中，研究卵巢类固醇、雌激素和黄体酮如何作用于血管壁和子宫内膜。六个月大的白化兔被分为六组； C（假手术）、OVX（卵巢切除术）、OVX+E（戊酸雌二醇；5mg/体/2周）、OVX+E+1.0P（17α-羟孕酮己酸酯；125mg/体/2周）、OVX+E+0.3P、Ovx+E+0.1P。这些兔子被提供含有 0.5% 胆固醇的商业饲料，并每两周给予这些类固醇。六个月后他们被终止，并制作样本用于显微镜和张力记录。 OVX胸主动脉中层厚度为844±78μm；比非胆固醇饲料粗2.5倍。顺序如下： OVX>OVX+E+1.0P>OVX+E+0.3P>OVX+E+0.1P>OVX+E>C。与上述相同的顺序，内皮依赖性松弛较小。另一方面，不同浓度黄体酮的兔子之间没有显着差异。似乎应该考虑这些浓度和受试者数量。总之，雌激素甚至在动脉粥样硬化血管中也能增强松弛作用，而黄体酮则减少了雌激素对中位肥厚的抑制作用。

项目成果

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緒方りか: "日本人女性の血管機能とHRT"日本更年期医学会雑誌. 7・1. 66-70 (1999)

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野崎雅裕: "閉経による心血管系の変化及びその機序に関する研究"日本産科婦人科学会雑誌. 49・8. 552-562 (1997)

野崎正弘：“绝经引起的心血管系统变化及其机制的研究”日本妇产科学会杂志49・8（1997）。

M. Nozaki, Y. Inoue, K. Hashimoto, R. Ogata, H. Nakano: "Differential time- related effects of conjugated equine estrogen on bone metabolism in oophorectomized women"Int. J. Gynecol. Obstet.. 60. 41-46 (1998)

M. Nozaki、Y. Inoue、K. Hashimoto、R. Ogata、H. Nakano：“结合马雌激素对卵巢切除女性骨代谢的不同时间相关影响”Int。

M.Nozaki,et al.: "Trearment of bone loss in oophorecimized women with a comoination or ipriflavone and conjugated equine estrogen." International Journal of Gynecology and Obstetrics. 62. 69-75 (1998)

M.Nozaki 等人：“用异丙黄酮和结合马雌激素治疗卵巢切除妇女的骨质流失。”