The relation of ultraviolet B exposure development cataract and acceleration of the progression of cataract opacification of atopic cataract expression mechanism.

应用Scheimpflg和镜片图像对特应性皮炎患者的晶状体合并白内障和不合并白内障进行了检查。白内障的变化与沃格特在20世纪30年代指出的变化基本相同。这些改变为浅前皮质和/或包膜下混浊。应用上述检查，又发现一例隐匿性白内障。作者提出的方法学对白内障的早期诊断具有临床应用价值。虽然血清IgE水平通常被认为是患者状态的一个指标，但白内障的出现与血清和房水中的IgE水平并没有显著的关系。由于强烈瘙痒而摩擦眼皮的习惯和长期服用类固醇并不是白内障的原始原因，但它们可能加速了白内障的进展。特应性皮炎相关的白内障具有特殊性，不同于外伤性和/或激素性白内障，其形成机制被认为是多种因素共同和/或合并性白内障的致病因素。在众多的危险因素中，对眼睛的太阳UV-B辐射目前被认为是白内障发生和发展的重要危险因素。在实验研究中，用感染尘螨的NC/NGA小鼠作为特应性皮炎的模型动物，检测到了白内障的形成。然而，根据对与NC/Nga品系相同的NC/Nga小鼠和NC/Num小鼠的长期观察，它们的白内障不是后天的，而是先天性的。尽管如此，感染尘螨的NC/Num小鼠可能是研究紫外线照射加速的白内障的进展和预防的有用动物。

The findings of lenses with and without cataract were detected in patients with atopic dermatitis by a newly developed examination applying Scheimpflug and specular images of the lens. The cataractous changes were fundamentally the same as those pointed out by Vogt in the 1930s. These changes were shallow anterior cortical and / or subcapsular opacification. By applying the above examinations, another cases with occult cataract were detected. The methodology proposed by the authors would be clinically useful for early cataract diagnosis. Although serum IgE level has often been considered as an indicator of the patients' state, there was no significant relationship between cataract appearance and IgE levels in serum and aqueous humor. The habit of rubbing the eyelid due to strong itching and long-term steroid administration were not the original causes for the cataract, but they may have accelerated cataract progression. The cataract associated with atopic dermatitis is specific and different from traumatic and/or steroid induced cataracts.Cataract formation mechanism has been considercd by multi-factorial risks, which act as co -and / or syn-cataract genic. Among the several risk factors, solar UV-B irradiation to the eyes is presently accepted as an important risk for cataract appearance and progression. In the experimental studies, cataract formation was detected from NC/Nga mice with mite infections which are used as a model animal for atopic dermatitis. However, according to long-term observation of NC/Nga mice and NC/Num mice which are the same strain as NC/Nga, their cataracts were not acquired, but congenital. Even so, NC/Num mice with mite infections may be useful animals to investigae the progression and prevention of cataracts which have been accelerated by UV exposure.