Improving Outcomes in Cataract Surgery: Intraocular Lenses (IOLs) Resistant to Cell Growth

改善白内障手术的效果:抗细胞生长的人工晶状体 (IOL)

基本信息

  • 批准号:
    10841859
  • 负责人:
  • 金额:
    $ 7.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

ABSTRACT Cataracts, a clouding of the natural lens, is the leading cause of blindness worldwide, with a projected 40M cases by 2050. Underrepresented groups and medically underserved populations are disproportionately impacted by cataracts. Clinical treatment is limited to surgical removal of the cataractous lens, and implantation of an intraocular lens (IOL). Unfortunately, the IOL is highly susceptible to growth from residual lens epithelial cells (LECs), a complication known as posterior capsule opacification (PCO) that occurs in ~40% of adult IOL patients. Laser capsulotomy surgery is used to treat PCO, but has significant potential side effects. The proposed work will lead to the development of “LEC-resistant IOLs” based on a new amphiphilic silicone, reducing the incidence of PCO and the need for a 2nd surgery (laser capsulotomy). This work is significant given not only the expected exceptional LEC-resistance and retention of desired opto-mechanical properties of the proposed IOLs (supported by preliminary data), but also that it relies on a strategy readily integrated into existing IOL materials, designs, and manufacturing processes. Diphenyl silicones are used to prepare foldable IOLs, wherein the elastomeric nature provides the ability to fold the IOL upon implantation such that the incision size may be reduced. In this work, new amphiphilic surface-modifying additives (SMAs) [developed by the PI], comprised of a poly(ethylene oxide) (PEO) segment and siloxane tether, will be readily blended into an IOL-type diphenyl silicone. These SMAs uniquely afford rapid and substantial migration to the aqueous/biological interface to produce LEC-resistance, without impacting opto-mechanical properties. The innovation of this work rests not only in the novelty of the PI-developed SMAs, but in the departure from other strategies that have attempted to produce IOLs with resistance to LEC growth (e.g., change to IOL geometric design, complex surface treatment, and reactive oxygen species (ROS)-producing modifiers). The approach to accomplish this work relies on a systematic and robust methods, and will be led by a team of skilled experts. In Aim 1 [led by Grunlan, PI], silicone formulations will be prepared with SMAs of varying structure and concentration in the diphenyl silicone, key material properties assessed, and IOLs prepared from formulations meeting success criteria. In Aim 2 [led by Chandler, Co-I] select formulations will be evaluated for resistance to LEC growth, and select IOLs assessed ex vivo in rabbit and human eyes with a commercial silicone IOL used as a control. Following iterations of Aim 1 and 2, in Aim 3 [led by Scott, Co-I), a SMA-modified IOL will be evaluated in a rabbit model, and biocompatibility and resistance to LEC growth compared to the commercial IOL. The clinical consultant, Dr. Lee, M.D. (a comprehensive ophthalmologist and ocular pathologist) will provide guidance to these studies.
摘要

项目成果

期刊论文数量(0)
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Melissa Grunlan其他文献

Melissa Grunlan的其他文献

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{{ truncateString('Melissa Grunlan', 18)}}的其他基金

Improving Outcomes in Cataract Surgery: Intraocular Lenses (IOLs) Resistant to Cell Growth
改善白内障手术的效果:抗细胞生长的人工晶状体 (IOL)
  • 批准号:
    10573497
  • 财政年份:
    2023
  • 资助金额:
    $ 7.82万
  • 项目类别:
Shape Memory Polymer Scaffolds to Treat Bone Defects in Patients with Alzheimer's Disease
形状记忆聚合物支架治疗阿尔茨海默病患者的骨缺损
  • 批准号:
    10442203
  • 财政年份:
    2020
  • 资助金额:
    $ 7.82万
  • 项目类别:
Shape Memory Polymer Scaffolds to Treat Bone Defects in Patients with Alzheimer's Disease
形状记忆聚合物支架治疗阿尔茨海默病患者的骨缺损
  • 批准号:
    10263155
  • 财政年份:
    2020
  • 资助金额:
    $ 7.82万
  • 项目类别:
Bioactive, "Self-fitting" Shape Memory Polymer (SMP) Scaffolds to Treat Cranial Bone Defects
生物活性“自贴合”形状记忆聚合物 (SMP) 支架可治疗颅骨缺损
  • 批准号:
    9240216
  • 财政年份:
    2017
  • 资助金额:
    $ 7.82万
  • 项目类别:
A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
自清洁膜可延长植入式葡萄糖生物传感器的使用寿命
  • 批准号:
    8803977
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:
A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
自清洁膜可延长植入式葡萄糖生物传感器的使用寿命
  • 批准号:
    8440044
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:
Hybrid Inorganic-Organic Hydrogel Scaffolds for Osteochondral Regeneration
用于骨软骨再生的混合无机-有机水凝胶支架
  • 批准号:
    8285559
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:
Hybrid Inorganic-Organic Hydrogel Scaffolds for Osteochondral Regeneration
用于骨软骨再生的混合无机-有机水凝胶支架
  • 批准号:
    8449051
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:
A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
自清洁膜可延长植入式葡萄糖生物传感器的使用寿命
  • 批准号:
    8918591
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:
A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
自清洁膜可延长植入式葡萄糖生物传感器的使用寿命
  • 批准号:
    8554303
  • 财政年份:
    2012
  • 资助金额:
    $ 7.82万
  • 项目类别:

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