INTRAPERITONEAL ADMINISTRATION DOXORUBICIN-LOADED HYDROXYAPATITESOL IN RATS WITH AH130 PERITONEAL CARCINOMATOSIS

对患有 AH130 腹膜癌的大鼠腹腔内施用负载阿霉素的羟基磷灰石醇

• 批准号: 09671328
• 负责人: MOHRI Noriaki
• 金额: $ 1.66万
• 依托单位: NAGOYA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671328/
• 关键词: HYDROXYAPTITE; DOXORUBICIN; AH130; INTRAPERITONEL ADMINISTRATION; DDS; DDS; AH130; ハイドロキシアパタイトゾル

(1) In vitro study, tumor cells were cultured in following 4 groups : 1)control ; 2) Hap - sol ; 3) DXR ; or 4) Hap - sol + DXR, number of tumor cells in the Hap - sol + DXR group increased least.(2) DXR adsorbed to the Hap -sol better than 5-FU or MMC.(3) DXR dose administered intraperitoneally in rats was deter minted to 1.5 mg/kg, adccoring to LD50 study.

(1)在体外实验中，将肿瘤细胞分为4组：1）对照组; 2）Hap-sol组; 3）DXR组; 4）Hap-sol + DXR组，Hap-sol + DXR组肿瘤细胞数增加最少。(2)DXR对Hap -sol的吸附作用优于5-FU和MMC. (3)大鼠腹腔注射DXR的剂量为1.5mg/kg，与LD_（50）比较。