Intestinal helminth infections and schistosomiasis and their relation to HIV-1 incidence, disease progression and immunology in Mbeya Region, Tanzania

坦桑尼亚姆贝亚地区肠道蠕虫感染和血吸虫病及其与 HIV-1 发病率、疾病进展和免疫学的关系

• 批准号: 82616928
• 负责人: Dr. Elmar Saathoff
• 金额: --
• 依托单位: Abteilung für Infektions- und Tropenmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/82616928?language=en
• 关键词: Intestinal; helminth; infections; schistosomiasis; their

We are proposing a prospective study into the epidemiology and immunology of helminth and HIV co-infection. The epidemiology component of the study will be conducted in an already established cohort of ~18,000 participants of all age groups in Southern Tanzania. Apart from generating highly relevant data about the influence of helminth infections on susceptibility to HIV infection and on disease progression, the study will also provide important insights into the regional epidemiology of a whole group of neglected infectious diseases of poverty.The immunology component (480 participants recruited from the above mentioned cohort) aims to compare the influence of different helminth infections on the immune system in general and on antigen-specific immune responses in particular in order to identify cellular parameters associated with HIV susceptibility and helminth induced immune-system modulation.Based at the excellent facilities of the Mbeya Medical Research Programme and implemented as a collaboration with Muhimbili University in Dar es Salaam and the University of Munich, the project will strengthen existing partnerships and will provide two Tanzanian researchers with scientific training and research experience and enable them to pursue academic degrees at Muhimbili University. Establishing helminthology as a research field in Mbeya will also lay the ground for further research capacity building and future studies in collaboration with our Tanzanian partners.

我们建议对蠕虫和HIV合并感染的流行病学和免疫学进行前瞻性研究。该研究的流行病学部分将在坦桑尼亚南部已建立的约1.8万名各年龄组参与者队列中进行。除了产生关于蠕虫感染对艾滋病毒易感性和疾病进展的影响的高度相关的数据外，这项研究还将提供对一整组被忽视的贫困传染病的区域流行病学的重要见解。免疫学部分（从上述队列中招募了480名参与者）旨在比较不同蠕虫感染对免疫系统的总体影响，特别是对抗原特异性免疫反应的影响，以确定与艾滋病毒易感性和蠕虫诱导的免疫系统调节相关的细胞参数。该项目以Mbeya医学研究方案的优良设施为基础，与达累斯萨拉姆的Muhimbili大学和慕尼黑大学合作实施，将加强现有的伙伴关系，并将为两名坦桑尼亚研究人员提供科学培训和研究经验，使他们能够在Muhimbili大学攻读学位。在Mbeya建立蠕虫学作为一个研究领域也将为进一步的研究能力建设和与我们的坦桑尼亚伙伴合作的未来研究奠定基础。