A pathogenic role of latent EB virus infection in cutaneous malignant lymphomas

我们的筛选试验结果表明，潜伏性EB病毒感染的频繁关联（超过80%），观察到在牛痘样水肿相关淋巴瘤和CD56+淋巴瘤，或血管中心性淋巴瘤。6例皮下淋巴瘤中4例（67%）、1例组织细胞样淋巴瘤伴蚊虫过敏和系统性噬血细胞增多症、2例眼睑或面部肿胀伴肌内浸润患者中发现大量EBER+细胞。在蕈样肉芽肿和Sezary综合征患者中没有发现EBV感染，我们发现所有12例临床和组织学上典型的种痘样水肿患儿的真皮浸润中均存在EBER+ T细胞。6例典型HV活检标本中5例经PCR证实存在EBV DNA序列。这些结果表明，典型HV的皮肤病变与EBER+细胞浸润相关，这表明具有恶性潜能的典型和非典型牛痘样水肿患者可能是EBV相关T细胞淋巴增殖性疾病相同疾病谱的变体。然而，目前还没有解释HV的光敏性与潜伏性EBV感染之间的关系。

Our screening test results demonstrated that the frequent association of latent EB virus infection (more than 80%) was observed in hydroa vacciniforme-related lymphomas and CD56+ lymphomas, or angiocentric lymphomas. A considerable number of EBER+ cells were found in 4 of 6 patients (67%) with subcutaneous lymphoma, a patient with histiocytoid lymphoma associated with mosquito allergy and systemic hemophagocytosis, and 2 patients with eyelid or facial swelling with intramuscular infiltration. No EBV infection was implicated in patients with mycosis fungoides and Sezary syndrome.We found that all 12 children with clinically and histologically typical hydroa vacciniforme had EBER+ T-cells in the dermal infiltrates. Furthermore, the presence of EBV DNA sequences was confirmed by PCR in 5 of 6 biopsy specimens from typical HV. These results indicate that the cutaneous lesions of typical HV are associated with infiltration of EBER+ cells, suggesting the possibility that both patients with typical and atypical hydroa vacciniforme with malignant potential are variants in the same disease spectrum of EBV-associated T-cell lymphoproliferative disorder. At the present time, however, no explanations have been made for the relationship between the photosensitivity in HV and the presence of latent EBV infection.