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An estimation of biological effects of rare earth elements on health of workers in high technology field

稀土元素对高技术领域从业人员健康的生物效应评估

基本信息

批准号：
09670365
负责人：
SHINOHARA Atsuko
金额：
$ 2.05万
依托单位：
Juntendo University School of Midicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670365/
关键词：
Rare earth elements Concentration in urine Workers in high technology field Index of rare earths exposure 生体影響評価 MIP-MS 産業衛生

项目摘要

To investigate the biological effects of rare earth elements on human health, distribution and excretion of administered rare earths in mice and excretion of them in human urine were studied. 1. Examination of a good index of exposure to rare earth elements : Adult male mice were intravenously administered with TbCl_3 a or YbCl_3 3 independently at 1 and 10 mg element/kg. Time-course and dose-dependent change in organ distribution and excretion in urine and feces were determined. The concentrations of administered elements in plasma decreased rapidly. The elements were distributed mainly in liver and spleen. Excretion of Th were smaller than Yb. Excretion amounts of Yb within 7 days in urine corresponded to 30 and 3% of administered dose in 1 and 10 mg/kg groups, respectively, and those of Tb corresponded to 11 and 0.5%. Excretion in feces corresponded from 10 to 16% of dose in all groups. These results suggested that the rare earth contents in urine were good index of exposure to trac … More e amounts of rare earths. 2. Concentrating method of rare earth elements : High-frequency plasma-mass can perform sensitive determination of rare earth elements at sub-ppb levels, however, is easily affected by coexisting elements. Since urine contains high levels of alkaline and alkaline earth elements the process for removing coexisting elements and for concentrating rare earth elements were examined. Two kinds of cheleting resin (Chelex 100 and Muromac A-1) were tested with bach and mini-column methods. Both resins were available and on-line column method with Muromac A-1 was adopted. 3. Application to urine sample : Recovery rate of rare earths from urine samples were 80% or more by this method. The element contamination of buffer and element elusion from electrode used for pH adjust were observed. 4. Determination of rare earth elements in human urine : Urine sample from control contained 0.01 ppb or less rare earths. The concentrations in urine from 25 workers of battery factory (Ni-Cd battery and Ni-H_2 second battery) were in the range from under detection limit to about 1 ppb. Father studies about normal range of rare earths concentrations in control persons and the relation between rare earths in worker's urine and their job, working periods are in progress. Less

为探讨稀土元素对人体健康的生物学效应，研究了稀土在小鼠体内的分布、排泄及人尿中的排泄。1.稀土元素良好暴露指数的检验：成年雄性小鼠分别静脉注射TbCl_3_a和YbCl_3_3，剂量分别为1和10 mg/kg。测定了器官分布和尿液和粪便排泄的时程和剂量依赖性变化。血浆中给药元素浓度迅速下降。元素主要分布在肝脏和脾脏中。Th的排泄量小于Yb。在1和10 mg/kg组中，7天内Yb在尿液中的排泄量分别相当于给药剂量的30%和3%，Tb的排泄量分别相当于给药剂量的11%和0.5%。在所有组中，粪便排泄量占剂量的10 - 16%。提示尿中稀土含量是一个较好的痕量稀土暴露指标 ...更多信息稀土元素的含量。2.稀土元素的富集方法：高频等离子体质谱法可以灵敏地测定亚ppb级的稀土元素，但易受共存元素的影响。由于尿液中含有高水平的碱金属和碱土金属元素，因此研究了去除共存元素和浓缩稀土元素的工艺。本文用Bach法和微柱法对两种螯合树脂（Chelex 100和Muromac A-1）进行了测定。两种树脂均可用，采用Muromac A-1在线柱法。3.尿样中稀土元素的回收率在80%以上。观察了缓冲液的元素污染和pH调节电极的元素析出。4.人尿中稀土元素的测定：对照尿样中稀土含量≤ 0.01 ppb。25名电池厂工人（镉镍电池和镍氢二次电池）尿中镉的浓度在低于检出限至约1 ppb范围内。本文还对正常人尿中稀土含量的正常范围及工人尿中稀土含量与工作、工龄的关系进行了研究。少