An epidemiological study for evaluation of organ derangement in hypertension using 24-hour ambulatory blood pressure monitoring and home blood pressure measurements.

近年来，许多生长因子和细胞因子被证实与动脉硬化有关，肝细胞生长因子（HGF）被报道与高血压有关。在本研究中，我们调查了肝细胞生长因子和高血压之间的关系，通过测量血清肝细胞生长因子浓度，并进行24小时动态血压监测（ABPM）在172名随机选择的男性和女性谁接受了医疗检查的循环系统疾病。受试者的平均血清HGF浓度为0.35± 0.14ng/ml。结果表明：1）血清HGF浓度与夜间收缩压和舒张压均呈正相关（2）血清HGF浓度与日间收缩压、舒张压均无相关性; 3）将夜间收缩压之差分为10 mmHg以下和10 mmHg以上两组时，肝细胞生长因子浓度明显高于对照组（0.39±0.14对0.30±0.12 ng/ml，p<0.05），同样，当夜间舒张压之间的差被分成小于5 mmHg的组和大于等于5 mmHg的组时，肝细胞生长因子浓度明显高于对照组（0.42±0.15对0.31±0.12 ng/ml，p<0.05）。另一方面，多元回归分析显示，年龄和偶然收缩压是高血压左室肥厚及其他脏器损害的显著解释变量。本研究将血清HGF水平作为反映高血压病器官损害的一个重要变量，提示ABPM测得的血压与血清HGF水平之间存在一定的相关性，这种相关性可能反映了高血压病对血管的损害。

In recent years, many growth factors and cytokines have been shown to be related to arteriosclerosis, and hepatocyte growth factor (HGF) has been reported to be associated with hypertension. In the present study, we investigated the relationship between HGF and hypertension by measuring the serum HGF concentration and performing 24-hour ambulatory blood pressure monitoring (ABPM) in 172 randomly selected male and female subjects who underwent a medical examination for circulatory disease. The mean serum HGF concentration in the subjects was 0.35±0.14 ng/ml. The results were as follows : 1) the serum HGF concentration was positively correlated with both the nighttime systolic and diastolic blood pressures (r=0.42, p<0.05 and r=O.47, p<0.01, respectively) ; 2) no correlation was found between serum HGF concentration and daytime systolic or diastolic blood pressure ; 3) when the difference between nighttime systolic blood pressures was divided into a group of less than 10 mmHg and a group of 10 mmHg or more, the HGF concentration was significantly higher in the former group (0.39±0.14 vs. 0.30±0.12 ng/ml, p<0.05), and, similarly, when the difference between nighttime diastolic blood pressures was divided into a group of less than 5 mmHg and a group of 5 mmHg or more, the HGF concentration was significantly higher in the former group (0.42±0.15 vs. 0.31±0.12 ng/ml, p<0.05).On the other hand, the multiple regression analysis shows that age and casual systolic blood pressure are the significant explanatory variable for LVH and other organ damages in hypertension. At this time, HGF serum levels are adopted as a significant variable for organ damages of hypertension.These results indicated that there is a relationship between blood pressure measured by ABPM and serum HGF concentration and that this relationship might reflect the damage to blood vessels in hypertension.