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An epidemiological study for evaluation of organ derangement in hypertension using 24-hour ambulatory blood pressure monitoring and home blood pressure measurements.

一项使用 24 小时动态血压监测和家庭血压测量评估高血压器官紊乱的流行病学研究。

基本信息

批准号：
09670405
负责人：
SAITOH Shigeyuki
金额：
$ 2.24万
依托单位：
Sapporo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

In recent years, many growth factors and cytokines have been shown to be related to arteriosclerosis, and hepatocyte growth factor (HGF) has been reported to be associated with hypertension. In the present study, we investigated the relationship between HGF and hypertension by measuring the serum HGF concentration and performing 24-hour ambulatory blood pressure monitoring (ABPM) in 172 randomly selected male and female subjects who underwent a medical examination for circulatory disease. The mean serum HGF concentration in the subjects was 0.35±0.14 ng/ml. The results were as follows : 1) the serum HGF concentration was positively correlated with both the nighttime systolic and diastolic blood pressures (r=0.42, p<0.05 and r=O.47, p<0.01, respectively) ; 2) no correlation was found between serum HGF concentration and daytime systolic or diastolic blood pressure ; 3) when the difference between nighttime systolic blood pressures was divided into a group of less than 10 mmHg and a group of 10 mmHg or more, the HGF concentration was significantly higher in the former group (0.39±0.14 vs. 0.30±0.12 ng/ml, p<0.05), and, similarly, when the difference between nighttime diastolic blood pressures was divided into a group of less than 5 mmHg and a group of 5 mmHg or more, the HGF concentration was significantly higher in the former group (0.42±0.15 vs. 0.31±0.12 ng/ml, p<0.05).On the other hand, the multiple regression analysis shows that age and casual systolic blood pressure are the significant explanatory variable for LVH and other organ damages in hypertension. At this time, HGF serum levels are adopted as a significant variable for organ damages of hypertension.These results indicated that there is a relationship between blood pressure measured by ABPM and serum HGF concentration and that this relationship might reflect the damage to blood vessels in hypertension.

近年来，许多生长因子和细胞因子被证明与动脉硬化有关，肝细胞生长因子（HGF）被报道与高血压有关。在本研究中，我们通过测量血清HGF浓度和24小时动态血压监测（ABPM）来研究HGF与高血压的关系，随机选择172名接受循环系统疾病医学检查的男性和女性受试者。受试者血清HGF平均浓度为0.35±0.14 ng/ml。结果表明：1)血清HGF浓度与夜间收缩压、舒张压呈正相关（r=0.42, p<0.05, r=0）；47, p<0.01)；2)血清HGF浓度与日间收缩压和舒张压无相关性；3)夜间收缩压差分为小于10 mmHg组和大于10 mmHg组时，前者HGF浓度显著高于前者（0.39±0.14 vs. 0.30±0.12 ng/ml, p<0.05），同样，夜间舒张压差分为小于5 mmHg组和大于5 mmHg组时，HGF浓度显著高于前者（p<0.05）。对照组HGF浓度显著高于对照组（0.42±0.15 vs. 0.31±0.12 ng/ml, p<0.05）。另一方面，多元回归分析显示，年龄和随意收缩压是高血压患者LVH及其他器官损害的重要解释变量。此时，血清HGF水平被作为高血压器官损害的重要变量。这些结果提示ABPM测血压与血清HGF浓度存在一定的关系，这种关系可能反映了高血压对血管的损害。