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Influence to atherosclerosis development of adiponecine and insulin resistance : A community base study

脂联素和胰岛素抵抗对动脉粥样硬化发展的影响：一项社区基础研究

基本信息

批准号：
15390206
负责人：
SAITOH Shigeyuki
金额：
$ 4.29万
依托单位：
Sapporo Medical University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Adiponectin, which is secreted specifically by adipose tissue, has been shown to have an anti-atherosclerotic effect and to improve insulin resistance. The aims of this study were to determine the correlations of plasma adiponectin concentration with insulin resistance, atherosclerosis and its risk factors and to determine the association between aging and adiponectin level from the aspect of influence of renal function and sex hormones in humans.The subjects were 383 male inhabitants in two rural communities in Hokkaido, Japan. A negative correlation was found between homeostasis model assessment (HOMA) as an index of insulin resistance and adiponectin concentration. hCRP and pulse wave velocity (PWV) were used as an index of atherosclerosis. Results of stepwise regression analysis for adiponectin showed that age, HOMA and serum triglyceride (TG) were independently correlated. with adiponectin. A significant negative correlation was found between adiponectin and hCRP in all subjects, and a significant negative correlation between adiponectin and PWV was also found.Serum adiponectin and blood urea nitrogen (BUN) levels were measured in 964 subjects aged 60ア 13 years. Testosterone and free testosterone levels were measured in 123 males, and estrone and estradiol levels were measured in 114 females. Adiponectin level increased linearly with aging in males, while it increased dramatically in females until their 50s. The patterns of changes in adiponectin were similar to those in BUN. In multiple regression analysis using adiponectin as a dependent variable, BUN was selected as a significant independent variable in subjects, while bioactive sex hormones were not selected as significant independent variables. A decrease in adiponectin clearance in the kidney may cause high levels of adiponectin in the elderly. Adiponectin level seems to be influenced more strongly by BUN than by sex hormones and to be increased by a decline in renal function with aging.

脂联素是由脂肪组织特异性分泌的，具有抗动脉粥样硬化和改善胰岛素抵抗的作用。本研究的目的是确定血浆脂联素浓度与胰岛素抵抗、动脉粥样硬化及其危险因素的相关性，并从肾功能和性激素的影响方面确定年龄与脂联素水平之间的关系，研究对象为日本北海道两个农村社区的383名男性居民。作为胰岛素抵抗指标的稳态模型评价（HOMA）与脂联素浓度呈负相关。以hCRP和脉搏波传导速度（PWV）作为动脉粥样硬化的指标。逐步回归分析结果显示年龄、HOMA、甘油三酯与脂联素水平呈独立相关。脂联素所有受试者的脂联素与hCRP呈显著负相关，脂联素与PWV也呈显著负相关。对964例60 ~ 13岁的受试者进行血清脂联素和血尿素氮（BUN）水平测定。在123名男性中测量睾酮和游离睾酮水平，在114名女性中测量雌酮和雌二醇水平。男性脂联素水平随增龄呈线性增加，女性脂联素水平在50岁以前显著增加。脂联素的变化规律与BUN相似。在以脂联素为因变量的多元回归分析中，选择血尿素氮作为受试者的显著自变量，而未选择生物活性性激素作为显著自变量。肾脏中脂联素清除率降低可能导致老年人脂联素水平升高。与性激素相比，BUN对脂联素水平的影响更大，随着年龄的增长，肾功能下降会增加脂联素水平。