Dioxin concentrations in the serum of workers at municipal waste incinerators

[目的]调查城市垃圾焚烧厂(MWIS)潜在接触者血清中多氯联苯并对二恶英(PCDDs)和多氯二苯并呋喃(PCDFs)浓度是否升高。在这14W1中，废物昼夜连续焚烧，废气中PCDDs/PCDFS的毒性当量(TEQ)分别为8.9-42、0.8-1.4和3.1-12 ng/Nm^3。在每个MWI中选择10名工人，并在同一城市选择10名与年龄(*5)匹配的职业非暴露工人。MWI组和对照组工人总数分别为30人和30人。每名工人早餐前采血(约100ml)，测定血清中PCDDs和PCDFS的浓度。但14W1作业工人血清中1，2，3，4，6，7，8-HEPTA CDF浓度均显著高于对照组。[结论]矿渣和飞灰中普遍含有高浓度的1，2，3，4，6，7，8-HEPTA CDD和L、2，3，4，6，7，8-HpCDF。在这三种物质中，由于对照组的血清1，2，3，4，6，7，8-HpCDF水平最低，故认为HpCDD的升高最为明显。这一发现表明，14W1工人职业暴露于PCDDs/PCDF。

[Objective] A survey was undertaken to confirm weather concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the serum of potentially exposed workers at municipal waste incinerators (MWIs) increased or not.[Methods] Three MWI (A, B and C) participated in this survey. In these 14W1, waste was continuously burned night and day, and the PCDDs/PCDFs concentrations in the exhaust gas were 8.9-42, 0.8-1.4 and 3.1-12 ng/Nm^3 as toxic equivalent quantity (TEQ), respectively. 10 workers were selected in each MWI, and 10 occupationally unexposed workers matched for age (*5) were selected in the same city. Total numbers of the MWI and control workers were 30 and 30, respectively. For each worker, blood sample (about 100 ml) was collected before the breakfast and concentrations of PCDDs and PCDFs were determined in the serum.[Results] There was not statistically significant difference in the TEQ value of the serum between the MWI and control workers. But significant increase of 1,2,3,4,6,7,8-hepta CDF concentration was found in the serum of the 14W1 workers comaperd with the control workers in all of the three MWI.[Conclusion] In general, slag and fly ash/contained 1,2,3,4,6,7,8-hepta CDD, octa CDD and l, 2,3,4,6,7,8-HpCDF at high concentration. In these three substances, because the serum level of 1,2,3,4,6,7,8-HpCDF was lowest in the control workers, it is considered that the increase in HpCDD was most detectable. This finding suggests that the 14W1 workers were occupationally exposed to PCDDs/PCDFs.