Dioxin concentrations in the serum of workers at municipal waste incinerators

[目的]调查城市垃圾焚烧厂（MWIs）作业工人血清中多氯二苯并二恶英（PCDDs）和多氯二苯并呋喃（PCDFs）浓度是否随天气变化而升高。[方法] 3个MWI（A、B、C）参加本次调查。在这些14 W1中，废物昼夜连续燃烧，废气中的PCDDs/PCDFs浓度分别为8.9-42、0.8-1.4和3.1-12 ng/Nm ^3（毒性当量）。每个MWI选择10名工人，并在同一城市选择10名年龄匹配的职业未暴露工人（*5）。MWI和对照组工人的总数分别为30和30。每名工人在早餐前采集血液样本（约100 ml），测定血清中PCDDs和PCDFs的浓度。[结果] MWI作业工人血清TEQ值与对照组比较差异无统计学意义。但14 W1作业工人血清中1，2，3，4，6，7，8-七肽CDF浓度在三种MWI下均显著高于对照组。[结论]炉渣和粉煤灰中普遍含有高浓度的1，2，3，4，6，7，8-heptaCDD、octaCDD和1，2，3，4，6，7，8-hpCDF。在这三种物质中，由于对照组工人血清中1，2，3，4，6，7，8-HpCDF的水平最低，因此认为HpCDD的升高是最可检测的。这一发现表明，14 W1工人在职业上接触了多氯二苯并对二恶英/多氯二苯并呋喃。

[Objective] A survey was undertaken to confirm weather concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the serum of potentially exposed workers at municipal waste incinerators (MWIs) increased or not.[Methods] Three MWI (A, B and C) participated in this survey. In these 14W1, waste was continuously burned night and day, and the PCDDs/PCDFs concentrations in the exhaust gas were 8.9-42, 0.8-1.4 and 3.1-12 ng/Nm^3 as toxic equivalent quantity (TEQ), respectively. 10 workers were selected in each MWI, and 10 occupationally unexposed workers matched for age (*5) were selected in the same city. Total numbers of the MWI and control workers were 30 and 30, respectively. For each worker, blood sample (about 100 ml) was collected before the breakfast and concentrations of PCDDs and PCDFs were determined in the serum.[Results] There was not statistically significant difference in the TEQ value of the serum between the MWI and control workers. But significant increase of 1,2,3,4,6,7,8-hepta CDF concentration was found in the serum of the 14W1 workers comaperd with the control workers in all of the three MWI.[Conclusion] In general, slag and fly ash/contained 1,2,3,4,6,7,8-hepta CDD, octa CDD and l, 2,3,4,6,7,8-HpCDF at high concentration. In these three substances, because the serum level of 1,2,3,4,6,7,8-HpCDF was lowest in the control workers, it is considered that the increase in HpCDD was most detectable. This finding suggests that the 14W1 workers were occupationally exposed to PCDDs/PCDFs.