Mortality risk from lung cancer among residents living near asbestos product plants

我们调查了居住在石棉制造厂附近的暴露于石棉的个人是否在三个地区经历了石棉相关疾病死亡率的增加。第一个队列研究表明，在1942 - 1991年期间，居住在每年使用数千吨铁石棉和温石棉的工厂附近的502个家庭的最高接触组中，肺癌死亡率显著增加，这表明邻近的石棉接触可导致肺癌。第二组研究表明，在1914年至2001年期间，在一家每年使用500吨温石棉的工厂附近居住的449户家庭的所有接触组中，与石棉有关的疾病死亡率并未增加。两个调查结果的差异可能是由于所用石棉的数量和类型不同所致。第三个队列研究表明，间皮瘤死亡率增加了52个家庭的男子生活在工厂附近使用每年3500吨温石棉1954年至1995年和每年4700吨青石棉1957年至1975年。这一发现表明，附近的石棉暴露可导致间皮瘤。

We investigated whether individuals exposed to asbestos by living near asbestos-manufacturing plants experienced increased asbestos related disease mortality in three areas. First cohort study showed that lung cancer mortality was significantly increased among the highest exposure group of 502 households living near a plant using annual several thousand tones of amosite and chrysotile from 1942 to 1991, which suggests that neighborhood asbestos exposure can cause lung cancer. Second cohort study showed that asbestos related disease mortalities were not increased among all exposure groups of 449 households living near a plant using annual 500 tones of chrysotile from 1914 to 2001. Difference between the two findings may be caused by difference in amount and type of used asbestos. Third cohort study showed that mesothelioma mortality was increased among men of 52 households living near a plant using annual 3500 tones of chrysotile from 1954 to 1995 and annual 4700 tones of crocidolite from 1957 to 1975. This finding suggests that neighborhood asbestos exposure can cause mesothelioma.