Receptor-functionalized Micelles and Vesicles of Amphiphilic Perylene Bisimide Dyes

两亲苝双酰亚胺染料的受体功能化胶束和囊泡

• 批准号: 83477742
• 负责人: Professor Dr. Frank Würthner
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/83477742?language=en
• 关键词: Receptor; functionalized; Micelles; Vesicles; Amphiphilic

Water-soluble micelles and vesicles will be prepared by co-self-assembly of amphiphlic perylene bisimides (PBI). The water-soluble PBI self-assemblies will be loaded with pH-sensitive fluorescence donors in the interior, and functionalized with crown ether receptors or positively charged spermine groups at the surface. These functional assemblies will be stabilized by in-situ photopolymerization of the double bonds at the side chain of PBI building block, and to give a new type of micellar nanoparticles bearing multivalent recognition sites. On the basis of fluorescence resonance energy transfer or photo-induced electron transfer mechanism, these water-soluble functional micelles and vesicles will display stimuliresponsive changes in emission color and intensity, and thus can be developed as effective, ratiometric and selective fluorescence sensors towards pH (hydrogen ion), alkali metal cation, or biomacromolecules such as DNA. By using fluorescence confocal microscopy, such functional fluorescence sensors will provide a direct visualization of the location, interaction, transport, distribution and dynamics of hydrogen ion (proton), cation, and biomacromolecule DNA.

通过两亲性苝酰亚胺（PBI）的自组装制备了水溶性胶束和囊泡。水溶性PBI自组装体将在内部装载ph敏感的荧光供体，并在表面与冠醚受体或带正电的精胺基团功能化。这些功能组合将通过PBI构建块侧链双键的原位光聚合来稳定，并提供一种具有多价识别位点的新型胶束纳米颗粒。基于荧光共振能量转移或光致电子转移机制，这些水溶性功能胶束和囊泡将显示出发射颜色和强度的刺激响应变化，从而可以开发为有效的、比例的和选择性的荧光传感器，用于pH（氢离子）、碱金属阳离子或生物大分子（如DNA）。通过使用荧光共聚焦显微镜，这种功能性荧光传感器将提供氢离子（质子）、阳离子和生物大分子DNA的位置、相互作用、运输、分布和动力学的直接可视化。