Regulation of acute phase protein gene expression by ascorbic acid.
抗坏血酸对急性期蛋白基因表达的调节。
基本信息
- 批准号:09660134
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The ODS rat, which has a hereditary defect in ascorbic acid biosynthesis, was used to investigate the effects of ascorbic acid deficiency on the hepatic gene expression of both the positive acute phase proteins, haptoglobin and alpha1-acid glycoprotein, and the negative acute phase proteins, apolipoprotein A-I and alubumin. Male ODS rats(6-week-old, body weight 140 g) were fed a diet containing ascorbic acid (300 mg/kg diet) or a diet without ascorbic acid for 14 days. Ascorbic acid deficiency significantly elevated the serum concentration of haptoglobin and significantly lowered those of apolipoprotein A-I and albumin. The hepatic mRNA levels of haptoglobin and alpha1-acid glycoprotein in the ascorbic acid-deficient rats were significantly elevated on day 12, and reached 260% and 360% of respective values in the control rats on day 14. On the contrary, the hepatic mRNA levels of apolipoprotein A-I and albumin in the ascorbic acid-deficient rats were lowered to 68% and 71% of respective values in the control rats on day 14. Although ascorbic acid deficiency significantly elevated the serum corticosterone concentration on day 14, the changes in mRNA levels of haptoglobin, alpha1-acid glycoprotein, apolipoprotein A-I and albumin due to ascorbic acid deficiency were not affected by adrenalectomy, as assesed in a separate experiment. The serum concentration of interleukin-6, an inflammatory cytokine that stimulates gene expression of some acute phase proteins, was significantly higher in the ascorbic acid-deficient rats on day 14 than in the control rats. These results suggest that ascorbic acid deficiency causes physiologic changes similar to those that occur in the acute phase response.
采用抗坏血酸生物合成存在遗传缺陷的ODS大鼠,研究抗坏血酸缺乏对阳性急性期蛋白(触珠蛋白和α 1-酸性糖蛋白)和阴性急性期蛋白(载脂蛋白)肝脏基因表达的影响。A-I和白蛋白。雄性ODS大鼠(6周龄,体重140 g)喂食含抗坏血酸的饮食(300 mg/kg饮食)或不含抗坏血酸的饮食14天。抗坏血酸缺乏显著升高血清结合珠蛋白的浓度,显着降低载脂蛋白A-I和白蛋白。抗坏血酸缺乏大鼠的肝结合珠蛋白和α 1-酸性糖蛋白的mRNA水平在第12天显著升高,并在第14天达到对照大鼠相应值的260%和360%。相反,在第14天,抗坏血酸缺乏大鼠的载脂蛋白A-I和白蛋白的肝脏mRNA水平分别降低至对照大鼠相应值的68%和71%。虽然抗坏血酸缺乏显着升高血清皮质酮浓度在第14天,结合珠蛋白,α 1-酸性糖蛋白,载脂蛋白A-I和白蛋白的mRNA水平的变化,由于抗坏血酸缺乏不受肾上腺切除术,在一个单独的实验评估。白细胞介素-6的血清浓度,刺激一些急性期蛋白的基因表达的炎性细胞因子,显着高于抗坏血酸缺乏大鼠在第14天比对照组大鼠。这些结果表明,抗坏血酸缺乏引起的生理变化类似于那些发生在急性期反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ikeda, S., Horio, F.and Kakinuma, A.: "Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats." J.Nutr.128. 832-838 (1998)
Ikeda, S.、Horio, F. 和 Kakinuma, A.:“抗坏血酸缺乏会改变坏血病倾向 ODS 大鼠急性期蛋白的肝脏基因表达。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
堀尾文彦: "アスコルビン酸欠乏時の急性期タンパク質の発現変動" ビタミン. 72. 113-114 (1998)
Fumihiko Horio:“抗坏血酸缺乏期间急性期蛋白表达的变化”维生素。72. 113-114 (1998)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ikeda,S., Horio,F.and Kakinuma,A.: "Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats." Journal of Nutrition. 128. 832-838 (1998)
Ikeda,S.、Horio,F. 和 Kakinuma,A.:“抗坏血酸缺乏会改变易患坏血病的 ODS 大鼠中急性期蛋白的肝脏基因表达。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ikeda, S.: "Ascorbic acid deficiency decreases the renal level of kindney fatty acid-binding protein by lowering the α2u-globulin gene expresion in liver in scurvy-prone ODS rats." J.Nutr.127. 2173-2178 (1997)
Ikeda, S.:“抗坏血酸缺乏通过降低易患坏血病的 ODS 大鼠肝脏中的 α2u 球蛋白基因表达来降低肾脏脂肪酸结合蛋白的水平。”J.Nutr.127 (1997)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ikeda, S., Takasu, M., Matsuda, T., Kakinuma, A.and Horio, F.: "Ascorbic acid deficiency decreases the renal level of kidney fatty acid-binding protein by lowering the a2u-globulin gene expression in liver in scurvy-prone ODS rats." J.Nutr.127. 2173-2178
Ikeda, S.、Takasu, M.、Matsuda, T.、Kakinuma, A. 和 Horio, F.:“抗坏血酸缺乏通过降低肝脏中 a2u 球蛋白基因表达来降低肾脏脂肪酸结合蛋白的水平
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HORIO Fumihiko其他文献
HORIO Fumihiko的其他文献
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{{ truncateString('HORIO Fumihiko', 18)}}的其他基金
Identification of diabetogenic and obesity genes by using nucleotides sequence variations between SM/J and A/J mice.
利用 SM/J 和 A/J 小鼠之间的核苷酸序列变异鉴定糖尿病和肥胖基因。
- 批准号:
24380068 - 财政年份:2012
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Pioneer study on the protective effect of ascorbic acid on barrier function of gastrointestinal tract
抗坏血酸对胃肠道屏障功能保护作用的开创性研究
- 批准号:
22658042 - 财政年份:2010
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Identification of the diabetogenic gene and its related genes of high fat diet-induced diabetes by using novel mouse model
利用新型小鼠模型鉴定高脂饮食诱发糖尿病的致糖尿病基因及其相关基因
- 批准号:
21380079 - 财政年份:2009
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Identification of causative gene for type 2 diabetes in SMXA-5 mouse feeding a high fat diet.
鉴定喂养高脂肪饮食的 SMXA-5 小鼠 2 型糖尿病致病基因。
- 批准号:
15580105 - 财政年份:2003
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The analysis of inflammation-like response caused by ascorbic acid deficiency in ODS rats unable to synthesize ascorbic acid.
无法合成抗坏血酸的ODS大鼠抗坏血酸缺乏引起的炎症样反应分析。
- 批准号:
13660121 - 财政年份:2001
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Establishment of a novel strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis, and the effect of ascorbic acid deficiency on the hypertension
抗坏血酸生物合成缺陷型自发性高血压大鼠新品系的建立及抗坏血酸缺乏对高血压的影响
- 批准号:
11660125 - 财政年份:1999
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Genetic analysis of diabetes in SMXA recombinant inbred strain of mice.
SMXA重组近交系小鼠糖尿病的遗传分析。
- 批准号:
11556024 - 财政年份:1999
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The roles of bilirubin and ascorbic acid as physiological antioxidant against oxidative stress.
胆红素和抗坏血酸作为生理抗氧化剂对抗氧化应激的作用。
- 批准号:
07660160 - 财政年份:1995
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of apolipoprotein A-I gene expression by ascorbic acid in scurvy-prone ODS-od/od rats.
抗坏血酸对易患坏血病的 ODS-od/od 大鼠中载脂蛋白 A-I 基因表达的调节。
- 批准号:
05660136 - 财政年份:1993
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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