Development and its Application of Functional Membranes by Molecular Imprint Technique via Phase Inversion Precipitation

采用相转化法制备了茶碱分子印迹膜。将具有THO模板的二甲基亚砜（DMSO）的共聚物浇铸溶液浸入水中，然后使包括模板的聚合物在非溶剂中凝结。从固化的共聚物膜中除去模板后，与咖啡因识别相比，识别出对THO分子的高选择性。模板剂浓度、聚合条件和共聚物中羧酸含量对分子印迹过程均有影响。THO分子印迹聚合物膜对THO分子的高选择性结合是由于THO分子印迹位点的形成，这些位点由羧酸链段上的自由OH基团与溶质形成氢键

Phase inversion of polyacrylonitrile copolymers with carboxylic acid groups was applied to prepare molecular imprinting membranes of theophylline (THO). The copolymer cast solution of dimethylsulfoxide (DMSO) with the THO template was immersed in water and then the polymer including the template is coagulated in the nonsolvent. After removal of the template from the solidified copolymer membrane, high selectivity for THO molecule was recognized compared to Caffeine recognition by the THO imprinted-membranes. The molecular imprint process was affected by the template concentration in the DMSO cast solution, coagulation condition and carboxylic acid contents in the copolymer. The high binding selectivity of THO solute to the THO imprinted copolymer membrane arise from the formation of the imprinted sites, which consist of free OH group of carboxylic acid segments for hydrogen bonds with the solute