Development and its Application of Functional Membranes by Molecular Imprint Technique via Phase Inversion Precipitation

采用含羧基的聚丙烯腈共聚物的相转化法制备了茶碱分子印迹膜。将二甲基亚砜(DMSO)与THO模板的共聚物铸造液浸泡在水中，然后将包括模板的聚合物凝聚在非溶剂中。在从固化的共聚物膜中去除模板后，与THO印迹膜识别咖啡因相比，THO分子的选择性更高。分子印迹过程受DMSO铸膜液中模板浓度、凝聚条件和共聚物中羧酸含量的影响。溶质对THO印迹共聚物膜的高结合选择性源于印迹中心的形成，印迹中心由用于与溶质氢键的羧酸链段的自由OH基团组成

Phase inversion of polyacrylonitrile copolymers with carboxylic acid groups was applied to prepare molecular imprinting membranes of theophylline (THO). The copolymer cast solution of dimethylsulfoxide (DMSO) with the THO template was immersed in water and then the polymer including the template is coagulated in the nonsolvent. After removal of the template from the solidified copolymer membrane, high selectivity for THO molecule was recognized compared to Caffeine recognition by the THO imprinted-membranes. The molecular imprint process was affected by the template concentration in the DMSO cast solution, coagulation condition and carboxylic acid contents in the copolymer. The high binding selectivity of THO solute to the THO imprinted copolymer membrane arise from the formation of the imprinted sites, which consist of free OH group of carboxylic acid segments for hydrogen bonds with the solute