Development and its Application of Functional Membranes by Molecular Imprint Technique via Phase Inversion Precipitation

采用羧基聚丙烯腈共聚物相转化法制备了茶碱分子印迹膜。将二甲基亚砜（DMSO）与THO模板的共聚物铸型溶液浸泡在水中，然后将包含模板的聚合物在非溶剂中凝固。从固化共聚物膜上去除模板后，与THO印迹膜对咖啡因的识别相比，THO印迹膜对THO分子的选择性更高。印迹过程受DMSO铸型溶液中模板浓度、混凝条件和共聚物中羧酸含量的影响。THO溶质对THO印迹共聚物膜的高选择性是由于印迹位点的形成，这些印迹位点由羧酸段的游离OH组成，与溶质形成氢键

Phase inversion of polyacrylonitrile copolymers with carboxylic acid groups was applied to prepare molecular imprinting membranes of theophylline (THO). The copolymer cast solution of dimethylsulfoxide (DMSO) with the THO template was immersed in water and then the polymer including the template is coagulated in the nonsolvent. After removal of the template from the solidified copolymer membrane, high selectivity for THO molecule was recognized compared to Caffeine recognition by the THO imprinted-membranes. The molecular imprint process was affected by the template concentration in the DMSO cast solution, coagulation condition and carboxylic acid contents in the copolymer. The high binding selectivity of THO solute to the THO imprinted copolymer membrane arise from the formation of the imprinted sites, which consist of free OH group of carboxylic acid segments for hydrogen bonds with the solute