Assessment of tumorigenic potential of human induced pluripotent stem cell-derived neural stem/progenitor cells for spinal cord injury

评估人诱导多能干细胞来源的神经干/祖细胞对脊髓损伤的致瘤潜力

• 批准号: 15K10422
• 负责人: IWANAMI AKIO
• 金额: $ 3.08万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10422/
• 关键词: 脊髄損傷; 神経幹細胞; iPS細胞; 再生医療; 腫瘍化

项目成果

Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.

通过带有磁场的程序冷冻机冷冻保存人类诱导多能干细胞衍生的神经干细胞和祖细胞的安全有效的方法。

• DOI: 10.1016/j.neures.2015.11.011
• 发表时间: 2016
• 期刊: Neurosci Res.
• 作者: Nishiyama Y;Iwanami A;Kohyama J;Itakura G;Kawabata S;Sugai K;Nishimura S;Kashiwagi R;Yasutake K;Isoda M;Matsumoto M;Nakamura M;Okano H.
• 通讯作者: Okano H.

Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.

• DOI: 10.1038/s41598-017-13522-w
• 发表时间: 2017-10-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Itakura G;Ozaki M;Nagoshi N;Kawabata S;Nishiyama Y;Sugai K;Iida T;Kashiwagi R;Ookubo T;Yastake K;Matsubayashi K;Kohyama J;Iwanami A;Matsumoto M;Nakamura M;Okano H
• 通讯作者: Okano H

ヒトiPS細胞を用いた脊髄再生医療に向けた安全性の確立

使用人类 iPS 细胞建立脊髓再生医学的安全性

• 发表时间: 2015
• 作者: Sugai K;Fukuzawa R;Shofuda T;Fukusumi H;Kawabata S;Nishiyama Y;Higuchi Y;Kawai K;Isoda M;Kanematsu D;Hashimoto-Tamaoki T;Kohyama J;Iwanami A;Suemizu H;Ikeda E;Matsumoto M;Kanemura Y;Nakamura M;Okano H.;岩波明生
• 通讯作者: 岩波明生

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives.

• DOI: 10.1016/j.stemcr.2017.02.003
• 发表时间: 2017-03-14
• 期刊: Stem cell reports
• 影响因子: 5.9
• 作者: Itakura G;Kawabata S;Ando M;Nishiyama Y;Sugai K;Ozaki M;Iida T;Ookubo T;Kojima K;Kashiwagi R;Yasutake K;Nakauchi H;Miyoshi H;Nagoshi N;Kohyama J;Iwanami A;Matsumoto M;Nakamura M;Okano H
• 通讯作者: Okano H

Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury.

• DOI: 10.1016/j.stemcr.2016.08.015
• 发表时间: 2016-10-11
• 期刊: STEM CELL REPORTS
• 影响因子: 5.9
• 作者: Okubo, Toshiki;Iwanami, Akio;Kohyama, Jun;Itakura, Go;Kawabata, Soya;Nishiyama, Yuichiro;Sugai, Keiko;Ozaki, Masahiro;Iida, Tsuyoshi;Matsubayashi, Kohei;Matsumoto, Morio;Nakamura, Masaya;Okano, Hideyuki
• 通讯作者: Okano, Hideyuki