Immunopathologic studies of oral lichen planus

口腔扁平苔藓的免疫病理学研究

• 批准号: 09470449
• 负责人: NAGURA Hideaki
• 金额: $ 2.88万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470449/
• 关键词: Oral lichen planus; T cells; HLA; DRB1; DQB1; DPB1; DQB1; DPB1; CD40

Oral lichen planus (OLP) is one of the most common oral mucosal diseases. Clinically, OLP frequently presents as multiple white lacy lesions that occur most commonly on the buccal mucosa and tongue. Histologically, OLP is characterized by a dense band-like lymphocytic infiltrate in the immediate sub-epithelial region with basal epithelial cell destruction. Etiologies for OLP remain unknown, although the pathogenesis of the disease is considered to involve cell-mediated immunity. In this studies, we have examined immunohistochemical investigation and human leukocyte antigens (HLA) typing in OLP.Immunohistochernical study indicated that the OLP lymphocyte infiltrate comprises principally T cells. These T cells were observed to be close to the damaged basement membrane. Numbers of T lymphocytes were significantly increased in erosive OLP tissue compared with normal epithelium (p<O.05). Numbers of cells expressing HLA class II (HLA-DR, DQ, DP) were also increased in erosive OLP epithelium … More compared with normal (p<O.O5). However, MIB-l-positive cells did not differ significantly. Thus, HLA-II-positive cells may be activating infiltrating T cells and causing damaging epithelium.HLA are cell-surface receptors that are fundamental to cell-to-cell interaction in all immunologic responses. In many instances, close associations have been found between disease susceptibility and the response of one or more specific HLA.Therefore, we determined the frequency of HLA class I and class II antigens on lymphocytes in Japanese patients with OLP.The study group consisted 17 OLP patients and 17 control. The frequency of HLA-A2, All, B35, Cwl and Cw7 may be increased in OLP.We also studied HLA-DRB1, DQB 1 and DPB 1 alleles. Slight increase in the frequency of DRB1*0405, DQB1*0301 and DQB1*0401 found in a group of OLP patients. However, there were no significant differences in the frequency of HLA between OLP patients and control. We will be studding HLA typing in a number of OLP patients and control. Less

口腔扁平苔藓（Oral lichen planus，OLP）是最常见的口腔粘膜疾病之一。临床上，口腔扁平苔藓常表现为多发性白色花边样病变，最常见于颊粘膜和舌。在组织学上，OLP的特征是在直接的上皮下区域中的致密带状淋巴细胞浸润，伴有基底上皮细胞破坏。OLP的病因仍不清楚，尽管该疾病的发病机制被认为涉及细胞介导的免疫。本研究对OLP进行了免疫组化和人类白细胞抗原（HLA）分型，免疫组化研究表明OLP淋巴细胞浸润主要由T细胞组成。观察到这些T细胞靠近受损的基底膜。糜烂型OLP组织中T淋巴细胞数量明显高于正常上皮（p<0.05）。糜烂型OLP上皮中表达HLA-DR、DQ、DP的细胞数增多 ...更多信息 与正常对照组比较，P<0.05。然而，MIB-1阳性细胞没有显著差异。因此，HLA-II阳性细胞可能激活浸润性T细胞并引起上皮损伤。HLA是细胞表面受体，在所有免疫应答中对细胞间相互作用至关重要。在许多情况下，已发现疾病易感性和一个或多个特定HLA.Therefore，我们确定了日本OLP患者淋巴细胞上的HLA I类和II类抗原的频率之间的密切联系。HLA-A2、A11、B35、Cw 1、Cw 7在OLP中的分布频率可能增高，并对HLA-DRB 1、DQB 1、DPB 1等位基因进行了研究。DRB 1 *0405、DQB 1 *0301和DQB 1 *0401在一组OLP患者中的频率略有增加。但OLP患者与对照组之间的HLA频率无显著性差异。我们将在一些OLP患者和对照组中进行HLA分型研究。少