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Structural investiga tions for developing therapeutics of functional disorders due to the sodium channel

Structural investiga tions for developing therapeutics of functional disorders due to the sodium channel
开发钠通道功能障碍疗法的结构研究
批准号:
09470493
负责人:
KURODA Yoshihiro
金额:
$8.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999

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中文摘要
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英文摘要
1. The tertiary amine type local anesthetics which possess a charge under physiological conditions interact hydrophobically with the phenylalanine residue in the hydrophobic motif, IMF, of the III-IV linker and also electrostatically with the acidic amino acid residues which locate before and after the IMF motif.2. At a similar condition as above, benzocaine locates at a polarhead-group region as in the case of the tertiary amine type local anes the tics, but cannot interact with the III-IV linker.3. The structure at around the IMF motifis generally α-helical. The structure at around the IMF motifis controlled by a hydrogen bonding between the isoleucine in the IMF and the threonine which take a position just after the IMF residues.4. A pentapeptide KIFMK interacts specifically with the III-IV linker and stabilizes the α-helical structure at around the structure of the IMF motif.As a therapeutic for paramyotonia congenita (PMC), in which the threonine is mutated into methionine, it is considered that a molecule which can stabilize the α-helical structure formed by the IFMT motifin the wild type sodium can be a good drug.
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Yoshihiro Kuroda: "ィイD11ィエD1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel in activation gate peptides as ca us ed by the pentapep tide KIFMK"Biophysical Journal. 77. 1363-1373 (1999)
Yoshihiro Kuroda:“由五肽 KIFMK 引起的激活门肽中钠通道二级结构变化的 D11D1H-NMR 和圆二色性光谱研究”生物物理学杂志 77. 1363-1373 (1999)。
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High quality haptic interaction with a soft body for remote collaboration
  • 批准号:
    24700117
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2012
  • 负责人:
    KURODA Yoshihiro
  • 依托单位:
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  • 批准号:
    22590076
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2010
  • 负责人:
    KURODA Yoshihiro
  • 依托单位:
Studies on inhibitors for epidermal growth factor receptor based on oligopeptides which imitated pseudosubstrates
Mechanisms of suppression of insulin signaling by Na channel blockers
  • 批准号:
    15590040
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.92万
  • 财政年份:
    2003
  • 负责人:
    KURODA Yoshihiro
  • 依托单位: