MOLECULAR ENVIRONMENT OF THE ACTION SITE OF ANESTHETICS

自从麻醉机制的研究开始以来，已经过去了一百多年。奥弗顿的脂类理论一直是物理化学家在这一领域的最基本理论。然而，这一理论只涉及麻醉剂分子如何存在于作用部位，而没有解释它们的作用机制。为什么影响脂膜理化参数的麻醉药浓度远高于临床浓度？另一方面，在临床浓度下可以观察到麻醉药对蛋白质的一些影响。因此，使用诸如神经递质和/或受体等蛋白质来研究麻醉机制正变得越来越流行。关于麻醉药对蛋白质的“特定”作用，已经发表了许多论文。为了获得有价值的理论，有必要对广泛的研究进行分析。因此，继续进行物理化学研究和生化研究是很重要的。该项目包括物理化学和生化研究人员。在项目期间，我们一起见了几次面，讨论了行动现场麻醉剂周围的环境如何。为了扩大讨论范围，我们举办了一次国际研讨会。我们邀请了来自不同领域关于麻醉机制的许多研究人员，进行了一次非常有意义的讨论。

More than a hundred years have passed since the study of mechanisms of anesthesia began. Overton's lipid theory has been the most fundamental theory for physicochemists in this field. However, this theory only dealt with how the anesthetic molecules exist in the action site, and did not explain the mechanisms of their action. Why are the concentrations of anesthetics that affect the physicochemical parameters of lipid membranes much higher than the clinical concentrations? On the other hand some effects of anesthetics on proteins can be observed at clinical concentrations. Therefore the use of proteins such as neurotransmitters and/or receptors for the study of anesthetic mechanisms is becoming popular. There have been many papers published regarding the "specific" action of anesthetics on proteins.In order to obtain a valuable theory, it is necessary to analyze a wide range of research. Therefore, it is important to continue physicochemical studies as well as biochemical studies. This project includes both physicochemical and biochemical investigators. During the project, we met together several times and discussed about how the environment around anesthetic at the action site is. To extend the discussion, we held an international workshop. Inviting many researchers from various fields concerning anesthetic mechanism, we have had a very meaningful talk.