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Drug and Species Differences of the Effects of Inhalational Anesthetics on the Behavior and / or Biological Response of Animals

吸入麻醉药对动物行为和/或生物反应影响的药物和物种差异

基本信息

批准号：
63480349
负责人：
OGLI Kenji
金额：
$ 4.16万
依托单位：
Kagawa Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Species differences were recognized on the effects of volatile anesthetics in Drosophila melanogasters and mice.Information from Drosophila study :The Gene which controls senditivity to an agent might be different from those to other agents, from the studies on ether, choloroform and halothane. An ether tolerant mutant was radiosensitive but it is not universal. Generally, ether anesthesia nonspecifically decreases the effect of radiation. Furthermore, the mutant of Na^+ channel, para ts2, is hypersensitive to ether anesthesia and it is suspected from the binding of para locus that the hypersensitivity links to any change of channel protein structure.Information from mouse study :Anesthetic induced opisthotonus was highly frequently found in ddN and YBR, and seldom found in C57BL and R3/IMR/Ki among 13 strains of mouse. The height of incidence due to anesthetics is in order of sevoflurane, isoflurane, enflurane, methoxyflurane and halothane. And the high incidence is also proportionate to the low value of blood/gas partition coefficient. In avoidance training, memory consolidation and retention are promoted by inhalation anesthesia. Central nervous system excitation of opisthotonus and memory promoting are not attributable to the same mechanism. Furthermore, strain-difference of sensitivity to volatile anesthetics was found. ddN strain showed higher ED_<50> of loss of righting reflex, C57BL showed lower ED_<50>. And F1 hybrid mice by reciprocal crossing between the two strains showed intermediate value in sevoflurane, enflurane and isoflurane. In halothane. individual ED_<50> was in the same range of value. The values of ED_<50> of F2 hybrid in Isoflurane and enflurane were in wide range. Free amino acids and catecholamines of mouse brain showed significant differences among strains, but these differences were not directly related to the sensitivity of anesthesia.

挥发性麻醉剂对果蝇和小鼠的影响存在物种差异。来自果蝇研究的信息：根据对乙醚、氯仿和氟烷的研究，控制对某种药物的敏感性的基因可能与对其他药物的敏感性不同。耐醚突变体对辐射敏感，但并不普遍。一般来说，乙醚麻醉非特异性地降低辐射的影响。此外，Na^+通道的突变体para ts2对乙醚麻醉过敏，从para位点的结合怀疑这种过敏与通道蛋白结构的任何变化有关。来自小鼠研究的信息：麻醉引起的角弓反张在ddN和YBR中非常常见，而在13个品系中的C57BL和R3/IMR/Ki中很少发现的鼠标。麻醉剂引起的发病率依次为七氟烷、异氟烷、安氟烷、甲氧氟烷和氟烷。其发病率高也与血气分配系数低成正比。在回避训练中，吸入麻醉可促进记忆巩固和保留。角弓反张的中枢神经系统兴奋和记忆促进并不是同一机制。此外，还发现了对挥发性麻醉剂的敏感性的应变差异。 ddN品系表现出较高的翻正反射丧失的ED_<50>，C57BL表现出较低的ED_<50>。两个品系之间相互杂交的F1杂交小鼠在七氟烷、安氟烷和异氟烷中显示出中间值。在氟烷中。各个ED_<50>处于相同的值范围内。 F2杂交体在异氟醚和安氟醚中的ED_<50>值范围较宽。小鼠脑游离氨基酸和儿茶酚胺在品系间存在显着差异，但这些差异与麻醉敏感性没有直接关系。