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Molecular Mechanisms Underlying Sperm-Eng Interaction

Molecular Mechanisms Underlying Sperm-Eng Interaction
精子与工程相互作用的分子机制
批准号:
09044210
负责人:
HOSHI Motonori
金额:
$3.39万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B).
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999

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中文摘要
翻译
在海星阿斯特里亚斯·阿穆伦斯中,鸡蛋的果冻外套、命名的跨组反应诱导物质(ARIS)、共ARIS和星形氮,在特别上讨论了同源spermatozoa以使跨组反应特殊的行为。ARIS是一种类似蛋白质的化合物,将其绑定到接收器本地化到精子头的外部部分中的一个小域。它的活动在很大程度上是有影响力的,由1000个或如此重复的硫代五硫代化合物链组成。Co-ARIS是一种由硫代类固醇和五氟代乙酰胺组成的皂苷。In combination with ARIS, it increases intracellular CaイイD12+イエD1 concentration of sperm。小球藻是一组富含谷氨酰胺的四肽,具有一个不饱和连接。它增加了cGMP水平和孔隙度的pH值,通过结合其受体,即主要孔隙膜蛋白中125 kDa的瓜尼酯循环酶。
英文摘要
In starfish Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concerted on homologous spermatozoa to elicit the acrosome reaction species-specifically. ARIS is proteoglycan-like compound which binds to the receptor localized to a small domain in the anterior portion of sperm heads. Its activity is mostly attributable to a sulfatedpolysaccharide chain composed of one thousand or so repeating units of a sulfated pentasaccharide. Co-ARIS is a group of saponins consisting of a sulfated steriod and a pentasaccharide. In combination with ARIS, it increases intracellular CaィイD12+ィエD1 concentration of sperm. Asterosap is a group of glutamine-rich tetratricontapeptides with a disulfide linkage. It increases cGMP level and intracellular pH of sperm through binding to its receptor that is the guanylate cyclase of 125 kDa in a major sperm membrane protein.
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会议论文
Kazuya Kobayashi: "Switching from asexual to sexual reproduction in the planarian Dugesia ryukyuensis : Bioassay system and basic description of sexualizing process"Zoological Science. 16. 291-298 (1999)
Kazuya Kobayashi:“涡虫Dugesia ryukyuensis从无性繁殖到有性繁殖的转变:生物测定系统和性化过程的基本描述”《动物学科学》。
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通讯作者:
Midori Matsumoto: "Sequence Analysis of cDNAs Encoding Precursors of Starfish asterosaps"Developmental Genetics. 25. 130-136 (1999)
Midori Matsumoto:“编码海星星体前体的 cDNA 的序列分析”发育遗传学。
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Kazuyoshi Chiba: "Induction of germinal vesicle breakdown in a cell-free preparation from starfish oocytes"Developmental Biology. 205. 217-223 (1999)
Kazuyoshi Chiba:“在海星卵母细胞的无细胞制剂中诱导生发囊泡分解”发育生物学。
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通讯作者:
Kazuyoshi Chiba: "Induction of Germinal vesicle breakdown in a cell-free preparation from stafish oocytes"Developmental Biology. 205. 217-223 (1999)
Kazuyoshi Chiba:“在海稳定卵母细胞的无细胞制剂中诱导生发囊泡分解”发育生物学。
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12
    Switching of Reproductive Strategy in planarian
    • 批准号:
      15370097
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.34万
    • 财政年份:
      2003
    • 负责人:
      HOSHI Motonori
    • 依托单位:
    A (2)
    Signal molecules in the jelly coat of starfish eggs for the inducing of acrosome reaction.
    • 批准号:
      08458237
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $5.44万
    • 财政年份:
      1996
    • 负责人:
      HOSHI Motonori
    • 依托单位:
    Fertilization and Development of the Lancelets
    • 批准号:
      07044186
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $2.69万
    • 财政年份:
      1995
    • 负责人:
      HOSHI Motonori
    • 依托单位:
    海外基金